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Author

Madou, Mark
BIO-MEMS Lab
Research Interests
  • Medical Diagnostics

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Genetically engineered protein in hydrogels tailors stimuli-responsive characteristics

Cited 151 times inthomson ciCited 137 times inthomson ci
Title
Genetically engineered protein in hydrogels tailors stimuli-responsive characteristics
Author
Ehrick, JDDeo, SKBrowning, TWBachas, LGMadou, MarkDaunert, S
Keywords
SENSITIVE HYDROGELS; BIOMOLECULAR MOTOR; DRUG-DELIVERY; RELEASE; NANODEVICE; POLYMERS; GELS
Issue Date
200504
Publisher
NATURE PUBLISHING GROUP
Citation
NATURE MATERIALS, v.4, no.4, pp.298 - 302
Abstract
A hybrid material that integrates genetically engineered proteins within hydrogels capable of producing a stimulus-responsive action mechanism was analyzed. Parametric studies were undertaken to understand the relationship between the extent of responsive swelling and the amounts of crosslinker and protein used to prepare the hydrogel. The stimuli-responsive hydrogel exhibited three specific swelling stages in response to various ligands offering additional fine-tuned control over a conventional two-stage swelling hydrogel. The prepared material was used in the sensing, and subsequent gating and transport of biomolecules across a polymer network, demonstrating its potential application in microfluidics and miniaturized drug-delivery systems.
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DOI
http://dx.doi.org/10.1038/nmat1352
ISSN
1476-1122
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