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DC Field | Value | Language |
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dc.citation.endPage | S299 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | S295 | - |
dc.citation.title | SMART MATERIALS AND STRUCTURES | - |
dc.citation.volume | 16 | - |
dc.contributor.author | Tsai, Han-Kuan A. | - |
dc.contributor.author | Ma, Kuo-Sheng | - |
dc.contributor.author | Wang, Chong | - |
dc.contributor.author | Xu, Han | - |
dc.contributor.author | Wang, Chunlei | - |
dc.contributor.author | Zoval, Jim | - |
dc.contributor.author | Kulinsky, Lawrence | - |
dc.contributor.author | Madou, Mark | - |
dc.date.accessioned | 2023-12-22T09:36:13Z | - |
dc.date.available | 2023-12-22T09:36:13Z | - |
dc.date.created | 2014-08-29 | - |
dc.date.issued | 2007-04 | - |
dc.description.abstract | A bi-layer structure comprising a thin gold layer and a polypyrrole (PPy) film is developed as a valve. To create such structures, the thin metal layer is used as a working electrode, and the polypyrrole film is electrochemically deposited on the metal electrode. A layer of Cr deposited under a stationary part of the bi-layer flap adheres strongly to the gold layer and anchors the hinge of the flap, while the layer of polyimide deposited under a movable part of the flap adheres weakly to the gold layer of the flap. This bi-layer flap structure functions as an actuator valve for the opening and closing of an aperture. The actuation mechanism of the valve is based on a volume change in the PPy layer as cations move in and out of the polymer film during reduction and oxidation reactions. A bias of 1.2 V is used to actuate the flap. A method is proposed to increase the drug release system's functionality by placing the drug release flap within a protective enclosure that also serves as a drug reservoir. This integrated protection ensures reliable operation of the drug release flap unencumbered by surrounding tissues when used in vivo. A prototype system using a PDMS drug reservoir has been successfully tested in PBS buffer solution. The proposed integrated protection system holds promise for implantable biomedical devices. | - |
dc.identifier.bibliographicCitation | SMART MATERIALS AND STRUCTURES, v.16, no.2, pp.S295 - S299 | - |
dc.identifier.doi | 10.1088/0964-1726/16/2/S14 | - |
dc.identifier.issn | 0964-1726 | - |
dc.identifier.scopusid | 2-s2.0-33947110953 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/5741 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33947110953 | - |
dc.identifier.wosid | 000244886100015 | - |
dc.language | 영어 | - |
dc.publisher | IOP PUBLISHING LTD | - |
dc.title | Development of integrated protection for a miniaturized drug delivery system | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | MICROACTUATORS | - |
dc.subject.keywordPlus | MICROSPHERES | - |
dc.subject.keywordPlus | FABRICATION | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | CHIP | - |
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