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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Selective activation of phospholipase D-2 by unsaturated fatty acid

Cited 71 times inthomson ciCited 72 times inthomson ci
Title
Selective activation of phospholipase D-2 by unsaturated fatty acid
Author
Kim, JHKim, YLee, SDLopez, IArnold, RSLambeth, JDSuh, Pann-GhillRyu, SH
Keywords
Oleic acid; Phosphatidylinositol 4,5-bisphosphate; Phospholipase D2
Issue Date
199907
Publisher
ELSEVIER SCIENCE BV
Citation
FEBS LETTERS, v.454, no.1-2, pp.42 - 46
Abstract
Although oleate has been implicated in the regulation of phospholipase D (PLD) activity, the molecular identity of the oleate-stimulated PLD is still poorly understood. We now report that oleate selectively stimulates the enzymatic activity of PLD2 but not of PLD1, with an optimal concentration of 20 μM in vitro. Intriguingly, phosphatidylinositol 4,5-bisphosphate (PIP2) synergistically stimulates the oleate-dependent PLD2 activity with an optimal concentration of 2.5 μM. These results provide the first evidence that oleate is a PLD2-specific activating factor and PLD2 activity is synergistically stimulated by oleate and PIP2.
URI
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DOI
http://dx.doi.org/10.1016/S0014-5793(99)00745-0
ISSN
0014-5793
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