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Author

Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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A role for nuclear phospholipase C beta(1) in cell cycle control

Cited 116 times inthomson ciCited 115 times inthomson ci
Title
A role for nuclear phospholipase C beta(1) in cell cycle control
Author
Faenza, IMatteucci, AManzoli, LBilli, AMAluigi, MPeruzzi, DVitale, MCastorina, SSuh, Pann-GhillCocco, L
Keywords
DIACYLGLYCEROL KINASE; SIGNAL-TRANSDUCTION; C BETA(1); 2 FORMS; DIFFERENTIATION; LOCALIZATION; PROGRESSION; PROTEIN; PHASE; G(1)
Issue Date
200009
Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Citation
JOURNAL OF BIOLOGICAL CHEMISTRY, v.275, no.39, pp.30520 - 30524
Abstract
Phosphoinositide signaling resides in the nucleus, and among the enzymes of the cycle, phospholipase C (PLC) appears as the key element both in Saccharomyces cerevisiae and in mammalian cells. The yeast PLC pathway produces multiple inositol polyphosphates that modulate distinct nuclear processes. The mammalian PLC beta(1), which localizes in the nucleus, is activated in insulin-like growth factor 1-mediated mitogenesis and undergoes down-regulation during murine erythroleukemia differentiation. PLC beta(1) exists as two polypeptides of 150 and 140 kDa generated from a single gene by alternative RNA splicing, both of them containing in the COOH-terminal tail a cluster of lysine residues responsible for nuclear localization. These clues prompted us to try to establish the critical nuclear target(s) of PLC beta(1) subtypes in the control of cell cycle progression. The results reveal that the two subtypes of PLC beta(1) that localize in the nucleus induce cell cycle progression in Friend erythroleukemia cells. In fact when they are overexpressed in the nucleus, cyclin D3, along with its kinase (cdk4) but not cyclin E is overexpressed even though cells are serum-starved. As a consequence of this enforced expression, retinoblastoma protein is phosphorylated and E2F-1 transcription factor is activated as well. On the whole the results reveal a direct effect of nuclear PLC beta(1) signaling in G(1) progression by means of a specific target, i.e. cyclin D3/cdk4.
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DOI
http://dx.doi.org/10.1074/jbc.M004630200
ISSN
0021-9258
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