Role of phospholipase C-gamma 1 in insulin-like growth factor I-induced muscle differentiation of H9c2 cardiac myoblasts
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- Role of phospholipase C-gamma 1 in insulin-like growth factor I-induced muscle differentiation of H9c2 cardiac myoblasts
- Hong, Feng; Moon, Keunai; Kim, Samsoo; Kim, Youngseol; Choi, Youngkil; Bae, Yunsoo; Suh, Pann-Ghill; Ryu, Sungho; Choi, Euiju; Ha, Joohun; Kim, Sungsoo
- ACTIVATED PROTEIN-KINASE; PHOSPHATIDYLINOSITOL 3-KINASE; C-GAMMA; MYOGENIC DIFFERENTIATION; TRANSCRIPTION FACTOR; SKELETAL MYOGENESIS; P38; PHOSPHORYLATION; INHIBITORS; ISOZYMES
- Issue Date
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.282, no.3, pp.816 - 822
- Insulin-like growth factor-I (IGF-I) regulates muscle differentiation through phosphatidylinositol 3-kinase (PI 3-kinase), Also it was recently reported that PI 3-kinase is involved in the activation of phospholipase C-gamma1 (PLC-gamma1), We investigated whether PLC-gamma1 therefore plays a role in IGF-I-induced muscle differentiation using H9c2 rat cardiac myoblasts as a model. IGF-I was able to activate PLC-gamma1 via both PI3-kinase-dependent and tyrosine phosphorylation-dependent mechanisms in this model. However, PI 3-kinase appeared to play a more important role than tyrosine phosphorylation in IGF-I activation of PLC-gamma1, In addition, PLC-gamma1. activation was independent of Akt/ protein kinase B (Akt/PKB), Importantly, PLC-gamma1 was involved in IGF-I-induced muscle differentiation in parallel with Akt/PKB, Taken together, these results suggest that IGF-I regulation of muscle differentiation is dependent on the activation of PLC-gamma1 and Akt/PKB, both of which are downstream mediators of PI 3-kinase.
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