Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE
Cited 119 times inCited 125 times in
- Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE
- Ye, KQ; Aghdasi, B; Luo, HBR; Moriarity, JL; Wu, FY; Hong, JJ; Hurt, KJ; Bae, SS; Suh, Pann-Ghill; Snyder, SH
- NERVE GROWTH-FACTOR; SH3 DOMAINS; CELL-DIFFERENTIATION; STRUCTURAL BASIS; FRIEND-CELLS; PROTEIN 4.1N; PC12 CELLS; C-GAMMA; RAS; ACTIVATION
- Issue Date
- NATURE PUBLISHING GROUP
- NATURE, v.415, no.6871, pp.541 - 544
- Phospholipase Cgamma1 (PLC-gamma1) hydrolyses phosphatidylinositol-4,5-bisphosphate to the second messengers inositol-1,4,5-trisphosphate and diacylglycerol. PLC-gamma1 also has mitogenic activity upon growth-factor-dependent tyrosine phophorylation(1,2); however, this activity is not dependent on the phospholipase activity of PLC-gamma1, but requires an SH3 domain(3,4). Here, we demonstrate that PLC-gamma1 acts as a guanine nucleotide exchange factor (GEF) for PIKE (phosphatidylinositol-3-OH kinase (PI(3)K) enhancer). PIKE is a nuclear GTPase that activates nuclear PI(3)K activity, and mediates the physiological activation by nerve growth factor (NGF) of nuclear PI(3)K activity(5). This enzymatic activity accounts for the mitogenic properties of PLC-gamma1.
- ; Go to Link
Appears in Collections:
- SLS_Journal Papers
can give you direct access to the published full text of this article. (UNISTARs only)
Show full item record
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.