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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE

Cited 119 times inthomson ciCited 125 times inthomson ci
Title
Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE
Author
Ye, KQAghdasi, BLuo, HBRMoriarity, JLWu, FYHong, JJHurt, KJBae, SSSuh, Pann-GhillSnyder, SH
Keywords
NERVE GROWTH-FACTOR; SH3 DOMAINS; CELL-DIFFERENTIATION; STRUCTURAL BASIS; FRIEND-CELLS; PROTEIN 4.1N; PC12 CELLS; C-GAMMA; RAS; ACTIVATION
Issue Date
200201
Publisher
NATURE PUBLISHING GROUP
Citation
NATURE, v.415, no.6871, pp.541 - 544
Abstract
Phospholipase Cgamma1 (PLC-gamma1) hydrolyses phosphatidylinositol-4,5-bisphosphate to the second messengers inositol-1,4,5-trisphosphate and diacylglycerol. PLC-gamma1 also has mitogenic activity upon growth-factor-dependent tyrosine phophorylation(1,2); however, this activity is not dependent on the phospholipase activity of PLC-gamma1, but requires an SH3 domain(3,4). Here, we demonstrate that PLC-gamma1 acts as a guanine nucleotide exchange factor (GEF) for PIKE (phosphatidylinositol-3-OH kinase (PI(3)K) enhancer). PIKE is a nuclear GTPase that activates nuclear PI(3)K activity, and mediates the physiological activation by nerve growth factor (NGF) of nuclear PI(3)K activity(5). This enzymatic activity accounts for the mitogenic properties of PLC-gamma1.
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DOI
http://dx.doi.org/10.1038/415541a
ISSN
0028-0836
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