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DC Field | Value | Language |
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dc.citation.endPage | 33974 | - |
dc.citation.number | 49 | - |
dc.citation.startPage | 33969 | - |
dc.citation.title | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.citation.volume | 283 | - |
dc.contributor.author | Lee, Yun Mi | - |
dc.contributor.author | Lee, Jung Ok | - |
dc.contributor.author | Jung, Jin-Hee | - |
dc.contributor.author | Kim, Ji Hae | - |
dc.contributor.author | Park, Sun-Hwa | - |
dc.contributor.author | Park, Ji Man | - |
dc.contributor.author | Kim, Eung-Kyun | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.contributor.author | Kim, Hyeon Soo | - |
dc.date.accessioned | 2023-12-22T08:14:50Z | - |
dc.date.available | 2023-12-22T08:14:50Z | - |
dc.date.created | 2014-09-03 | - |
dc.date.issued | 2008-12 | - |
dc.description.abstract | Retinoic acid (RA) is one of the major components of vitamin A. In the present study, we found that retinoic acid activated AMP-activated protein kinase (AMPK). RA induced Rac1-GTP formation and phosphorylation of its downstream target, p21-activated kinase (PAK), whereas the inhibition of AMPK blocked RA-induced Rac1 activation. Moreover, cofilin, an actin polymerization regulator, was activated when incubated with RA. We then showed that inhibition of AMPK by compound C, a selective inhibitor of AMPK, or small interfering RNA of AMPK α1 blocked RA-induced cofilin phosphorylation. Additionally, we found that retinoic acid-stimulated glucose uptake in differentiated C2C12 myoblast cells and activated p38 mitogen-activated protein kinase (MAPK). Finally, the inhibition of AMPK and p38 MAPK blocked retinoic acid-induced glucose uptake. In summary, our results suggest that retinoic acid may have cytoskeletal roles in skeletal muscle cells via stimulation of the AMPK-Rac1-PAK-cofillin pathway and may also have beneficial roles in glucose metabolism via stimulation of the AMPK-p38 MAPK pathway. | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOLOGICAL CHEMISTRY, v.283, no.49, pp.33969 - 33974 | - |
dc.identifier.doi | 10.1074/jbc.M804469200 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.scopusid | 2-s2.0-57749093010 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/5655 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=57749093010 | - |
dc.identifier.wosid | 000261277700023 | - |
dc.language | 영어 | - |
dc.publisher | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | - |
dc.title | Retinoic Acid Leads to Cytoskeletal Rearrangement through AMPK-Rac1 and Stimulates Glucose Uptake through AMPK-p38 MAPK in Skeletal Muscle Cells | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-KINASE | - |
dc.subject.keywordPlus | GROWTH-INHIBITION | - |
dc.subject.keywordPlus | CANCER CELLS | - |
dc.subject.keywordPlus | FATTY-ACID | - |
dc.subject.keywordPlus | ACTIN | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MOTILITY | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | CA2+ | - |
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