Crystal Structure of Filamentous Aggregates of Human DJ-1 Formed in an Inorganic Phosphate-dependent Manner
Cited 8 times inCited 8 times in
- Crystal Structure of Filamentous Aggregates of Human DJ-1 Formed in an Inorganic Phosphate-dependent Manner
- Cha, Sun-Shin; Il Jung, Ha; Jeon, Hyesung; An, Young Jun; Kim, In-Kwon; Yun, Sanguk; Ahn, Hyun Jin; Chung, Kwang Chul; Lee, Sang Hee; Suh, Pann-Ghill; Kang, Sa-Ouk
- FAMILIAL PARKINSONS-DISEASE; MULTIPLE SYSTEM ATROPHY; OXIDATIVE STRESS; DROSOPHILA DJ-1; ALPHA-SYNUCLEIN; PROTEIN DJ-1; CELL-DEATH; FERTILITY; L166P; INACTIVATION
- Issue Date
- AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
- JOURNAL OF BIOLOGICAL CHEMISTRY, v.283, no.49, pp.34069 - 34075
- Mutations in the DJ-1 gene have been implicated in the autosomal recessive early onset parkinsonism. DJ-1 is a soluble dimeric protein with critical roles in response to oxidative stress and in neuronal maintenance. However, several lines of evidence suggest the existence of a nonfunctional aggregated form of DJ-1 in the brain of patients with some neurodegenerative diseases. Here, we show that inorganic phosphate, an important anion that exhibits elevated levels in patients with Parkinson disease, transforms DJ-1 into filamentous aggregates. According to the 2.4-A crystal structure, DJ-1 dimers are linearly stacked through Pi-mediated interactions to form protofilaments, which are then bundled into a filamentous assembly.
- ; Go to Link
Appears in Collections:
- SLS_Journal Papers
can give you direct access to the published full text of this article. (UNISTARs only)
Show full item record
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.