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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Endothelial progenitor cell homing: prominent role of the IGF2-IGF2R-PLC beta 2 axis

Cited 57 times inthomson ciCited 51 times inthomson ci
Title
Endothelial progenitor cell homing: prominent role of the IGF2-IGF2R-PLC beta 2 axis
Author
Maeng, Yong-SunChoi, Hyun-JungKwon, Ja-YoungPark, Yong-WonChoi, Kyu-SilMin, Jeong-KiKim, Yun-HeeSuh, Pann-GhillKang, Kyung-SunWon, Moo-HoKim, Young-MyeongKwon, Young-Guen
Keywords
ACUTE MYOCARDIAL-INFARCTION; GROWTH-FACTOR II; MATRIX METALLOPROTEINASES; STEM-CELL; TUMOR ANGIOGENESIS; ARTERIAL INJURY; PRECURSOR CELLS; INSULIN; NEOVASCULARIZATION; RECEPTOR
Issue Date
200901
Publisher
AMER SOC HEMATOLOGY
Citation
BLOOD, v.113, no.1, pp.233 - 243
Abstract
Homing of endothelial progenitor cells (EPCs) to the neovascular zone is now considered to be an essential step in the formation of vascular networks during embryonic development and also for neovascularization in postnatal life. We report here the prominent role of the insulinlike growth factor 2 (IGF2)/IGF2 receptor (IGF2R) system in promoting EPC homing. With high-level expression of IGF2R in EPCs, IGF2-induced hypoxic conditions stimulated multiple steps of EPC homing in vitro and promoted both EPC recruitment and incorporation into the neovascular area, resulting in enhanced angiogenesis in vivo. Remarkably, all IGF2 actions were exerted predominantly through IGF2R-linked G(i) protein signaling and required intracellular Ca2 + mobilization induced by the β 2 isoform of phospholipase C. Together, these findings indicate that locally generated IGF2 at either ischemic or tumor sites may contribute to postnatal vasculogenesis by augmenting the recruitment of EPCs. The utilization of the IGF2/IGF2R system may therefore be useful for the development of novel means to treat angiogenesisdependent diseases.
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DOI
http://dx.doi.org/10.1182/blood-2008-06-162891
ISSN
0006-4971
Appears in Collections:
SLS_Journal Papers

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