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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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The roles of phospholipase D in EGFR signaling

Cited 23 times inthomson ciCited 20 times inthomson ci
Title
The roles of phospholipase D in EGFR signaling
Author
Lee, Chang SupKim, Kyung LockJang, Jin HyeokChoi, Yoon SupSuh, Pann-GhillRyu, Sung Ho
Keywords
Coordination; Epidermal growth factor receptor (EGFR); Interaction; Phospholipase D (PLD); Phox homology (PX) domain
Issue Date
200909
Publisher
ELSEVIER SCIENCE BV
Citation
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, v.1791, no.9, pp.862 - 868
Abstract
Epidermal growth factor receptor (EGFR) is a representative model of receptor tyrosine kinases (RTKs), and offers a means of understanding their common principles and fundamental mechanisms. Furthermore, EGFR plays an essential role in cell proliferation and migration, and the disruption of EGFR signaling has been implicated in the development and growth of cancer. Phospholipase D (PLD) is a key mediator of EGFR function, and can be directly regulated by upstream binding partners in an EGF-dependent manner. PLD regulates downstream molecules by generating phosphatidic acid (PA), but it also dynamically interacts with a variety of intracellular molecules and these interactions spatiotemporally regulate EGFR function and serve as a hub that orchestrates signaling flow. This review summarizes the interrelationship between PLD and its binding molecules in the context of EGFR signaling, and addresses the roles of PLD in the mediation and coordination of this signaling.
URI
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DOI
http://dx.doi.org/10.1016/j.bbalip.2009.04.007
ISSN
1388-1981
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SLS_Journal Papers

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