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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Sphingosine 1-phosphate induces vesicular endothelial growth factor expression in endothelial cells

Cited 15 times inthomson ciCited 17 times inthomson ci
Title
Sphingosine 1-phosphate induces vesicular endothelial growth factor expression in endothelial cells
Author
Heo, KyunPark, Kyung-AKim, Yun-HeeKim, Sun-HeeOh, Yong-SeokKim, In-HooRyu, Sung HoSuh, Pann-Ghill
Keywords
Angiogenesis; Endothelial cell; Promoter; Sphingosine 1-phosphate; Vascular endothelial cell growth factor
Issue Date
200910
Publisher
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
Citation
BMB REPORTS, v.42, no.10, pp.685 - 690
Abstract
Angiogenesis is essential for tumor growth and vascular endothelial cell growth factor (VEGF) plays a key role in this process. Conversely, sphingosine 1-phosphate (S1P) is a biologically active sphingolipid known to play a key role in cancer progression by regulating endothelial cell proliferation and migration. In this study, the authors found that S1P increases the level of VEGF mRNA in human umbilical vein endothelial cells (HUVECs) and immortalized HUVECs (iHUVECs). Additionally, S1P was found to increase VEGF promoter activity in MS-1 mouse pancreatic islet endothelial cells. Furthermore, a pharmacological inhibitory study revealed that Gαi/o-mediated phospholipase C, Akt, Erk, and p38 MAPK signaling are involved in this S1P-induced expression of VEGF. A component of AP1 transcription factor is important for S1P-induced VEGF expression. Taken together, these findings suggest that S1P enhances endothelial cell proliferation and migration by upregulating the expression of VEGF mRNA.
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ISSN
1976-6696
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