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Suh, Pann-Ghill
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dc.citation.endPage 892 -
dc.citation.number 6 -
dc.citation.startPage 885 -
dc.citation.title CANCER RESEARCH AND TREATMENT -
dc.citation.volume 26 -
dc.contributor.author Kim, Sungsook -
dc.contributor.author Cho, SooYeon -
dc.contributor.author Kim, KyungHee -
dc.contributor.author Kim, JungRan -
dc.contributor.author Lee, YoungHan -
dc.contributor.author Suh, Pann-Ghill -
dc.contributor.author Huh, ManHa -
dc.contributor.author Park, YoungHoon -
dc.date.accessioned 2023-12-22T13:06:03Z -
dc.date.available 2023-12-22T13:06:03Z -
dc.date.created 2014-09-03 -
dc.date.issued 1994-01 -
dc.description.abstract Phospholipase C isozymes (PLCs) play a role in ligand-mediated signal transduction for cellu- lar activity such as proliferation and differentation. However, their biological significance of in carcinogenesis or tumor progression is not fully estabilished, although PLC-rl is known to be related to the cell growth or the oncogene. We examined the relative content of PLC-rl in human hepatocellular carcinoma (HCC) and the adjacent non tumorous liver tissue, by immunoperoxidase staining of paraffin embedded sections. Among 32 cases, 25 demonstrated s significant decrease of PLC-rl content in comparison to the adjacent nontumorous tissue. Seven cases revealed no remarkable change in PLC-rl expression. There was no HCC expressing higher level of PLC-rl. We also performed image cytometric studies to evaluate the relationship between the DNA ploidy pattern and the PLC-yl content. Interestingly, the tumors showing a decreased PLC-rl expression, were mostly diploid and tetraploid (except 3 cases) in contrast to those tumors showing no change in PLC-rl content which were exclusively aneuploid. The results suggest that PLC-rl expression is closely related to DNA ploidy of the tumor, and that there may be two different mechanisms of hepatocarcinogenesis: one is related to PLC-rl associated signal trasduction system, and the other is independent of PLC-rl. -
dc.identifier.bibliographicCitation CANCER RESEARCH AND TREATMENT, v.26, no.6, pp.885 - 892 -
dc.identifier.issn 1598-2998 -
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/5622 -
dc.identifier.url http://www.cancer.or.kr/ -
dc.language 한국어 -
dc.publisher 대한암학회 -
dc.title.alternative Correlation of PLC-γ1 Expression and DNA Ploidy Pattern in Hepatocellular Carcinomas -
dc.title 간세포암종에서 Phospholipase C-γ1 의 발현과 DNA Ploidy 와의 관계 -
dc.type Article -

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