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DC Field | Value | Language |
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dc.citation.endPage | 892 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 885 | - |
dc.citation.title | CANCER RESEARCH AND TREATMENT | - |
dc.citation.volume | 26 | - |
dc.contributor.author | Kim, Sungsook | - |
dc.contributor.author | Cho, SooYeon | - |
dc.contributor.author | Kim, KyungHee | - |
dc.contributor.author | Kim, JungRan | - |
dc.contributor.author | Lee, YoungHan | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.contributor.author | Huh, ManHa | - |
dc.contributor.author | Park, YoungHoon | - |
dc.date.accessioned | 2023-12-22T13:06:03Z | - |
dc.date.available | 2023-12-22T13:06:03Z | - |
dc.date.created | 2014-09-03 | - |
dc.date.issued | 1994-01 | - |
dc.description.abstract | Phospholipase C isozymes (PLCs) play a role in ligand-mediated signal transduction for cellu- lar activity such as proliferation and differentation. However, their biological significance of in carcinogenesis or tumor progression is not fully estabilished, although PLC-rl is known to be related to the cell growth or the oncogene. We examined the relative content of PLC-rl in human hepatocellular carcinoma (HCC) and the adjacent non tumorous liver tissue, by immunoperoxidase staining of paraffin embedded sections. Among 32 cases, 25 demonstrated s significant decrease of PLC-rl content in comparison to the adjacent nontumorous tissue. Seven cases revealed no remarkable change in PLC-rl expression. There was no HCC expressing higher level of PLC-rl. We also performed image cytometric studies to evaluate the relationship between the DNA ploidy pattern and the PLC-yl content. Interestingly, the tumors showing a decreased PLC-rl expression, were mostly diploid and tetraploid (except 3 cases) in contrast to those tumors showing no change in PLC-rl content which were exclusively aneuploid. The results suggest that PLC-rl expression is closely related to DNA ploidy of the tumor, and that there may be two different mechanisms of hepatocarcinogenesis: one is related to PLC-rl associated signal trasduction system, and the other is independent of PLC-rl. | - |
dc.identifier.bibliographicCitation | CANCER RESEARCH AND TREATMENT, v.26, no.6, pp.885 - 892 | - |
dc.identifier.issn | 1598-2998 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/5622 | - |
dc.identifier.url | http://www.cancer.or.kr/ | - |
dc.language | 한국어 | - |
dc.publisher | 대한암학회 | - |
dc.title.alternative | Correlation of PLC-γ1 Expression and DNA Ploidy Pattern in Hepatocellular Carcinomas | - |
dc.title | 간세포암종에서 Phospholipase C-γ1 의 발현과 DNA Ploidy 와의 관계 | - |
dc.type | Article | - |
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