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김광수

Kim, Kwang S.
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Selective Fluorescent Detection of RNA in Living Cells by Using Imidazolium-Based Cyclophane

Author(s)
Shirinfar, BaharehAhmed, NisarPark, Yu ShinCho, Gun-SikYoun, Il SeungHan, Jin-KwanNam, Hong GilKim, Kwang S.
Issued Date
2013-01
DOI
10.1021/ja3112274
URI
https://scholarworks.unist.ac.kr/handle/201301/5571
Fulltext
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84872110959
Citation
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.135, no.1, pp.90 - 93
Abstract
A water-soluble imidazolium-based fluorescent chemosensor senses RNA selectively through fluorescence enhancement over other biologically relevant biomolecules in aqueous solution at physiological pH 7.4. Fluorescence image detection of RNA in living cells such as onion cells, HeLa cells, and animal model cells was successfully demonstrated which displays a chelation-enhanced fluorescence effect. These affinities can be attributed to the strong electrostatic (C-H)+⋯A- ionic H-bonding and the aromatic moiety driven π-stacking of imidazolium-based cyclophane with the size-complementary major groove of RNA.
Publisher
AMER CHEMICAL SOC
ISSN
0002-7863
Keyword
IN-SITU HYBRIDIZATIONPHYSIOLOGICAL PHMESSENGER-RNAANION RECOGNITIONAQUEOUS-SOLUTIONEXCIMER FORMATIONRECEPTORSPROBESCHEMOSENSORBINDING

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