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DC Field | Value | Language |
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dc.citation.endPage | 109 | - |
dc.citation.startPage | 103 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 577 | - |
dc.contributor.author | Shin, Kyeong Jin | - |
dc.contributor.author | Jang, Hyun-Jun | - |
dc.contributor.author | Lee, Yu Jin | - |
dc.contributor.author | Lee, Yu Geon | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.contributor.author | Yang, Yong Ryoul | - |
dc.contributor.author | Chae, Young Chan | - |
dc.date.accessioned | 2023-12-21T15:14:54Z | - |
dc.date.available | 2023-12-21T15:14:54Z | - |
dc.date.created | 2021-10-18 | - |
dc.date.issued | 2021-09 | - |
dc.description.abstract | As essential phospholipid signaling regulators, phospholipase C (PLC)s are activated by various extra cellular ligands and mediate intracellular signal transduction. PLC gamma 1 is involved in regulating various cancer cell functions. However, the precise in vivo link between PLC gamma 1 and cancer behavior remains undefined. To investigate the role of PLC gamma 1 in colorectal carcinogenesis, we generated an intestinal tissue-specific Plcg1 knock out (KO) in adenomatous polyposis coli (Apc)(Min/+) mice. Plcg1 deficiency in Apc(Min/+) mice showed earlier death, with a higher colorectal tumor incidence in both number and size than in wild-type mice. Mechanistically, inhibition of PLC gamma 1 increased the levels of its substrate phosphoinositol 4,5-bisphosphate (PIP2) at the plasma membrane and promoted the activation of Wnt receptor low-density lipoprotein receptor-related protein 6 (LRP6) by glycogen synthase kinase 3 beta (GSK3 beta) to enhance beta-catenin signaling. Enhanced cell proliferation and Wnt/beta-catenin signaling were observed in colon tumors from Plcg1 KO mice. Furthermore, low PLC gamma 1 expression was associated with a poor prognosis of colon cancer patients. Collectively, we demonstrated the role of PLC gamma 1 in vivo as a tumor suppressor relationship between the regulation of the PIP2 level and Wnt/beta-catenin-dependent intestinal tumor formation. (C) 2021 Elsevier Inc. All rights reserved. | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.577, pp.103 - 109 | - |
dc.identifier.doi | 10.1016/j.bbrc.2021.09.012 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.scopusid | 2-s2.0-85114414759 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/54171 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0006291X21013000?via%3Dihub | - |
dc.identifier.wosid | 000698503600004 | - |
dc.language | 영어 | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | Phospholipase C gamma 1 represses colorectal cancer growth by inhibiting the Wnt/beta-catenin signaling axis | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Biophysics | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Biophysics | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | GSK3 beta | - |
dc.subject.keywordAuthor | Tumor suppressor | - |
dc.subject.keywordAuthor | PLC gamma 1 | - |
dc.subject.keywordAuthor | PIP2 | - |
dc.subject.keywordAuthor | LRP6 | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | ROLES | - |
dc.subject.keywordPlus | PIP2 | - |
dc.subject.keywordPlus | C-GAMMA | - |
dc.subject.keywordPlus | RECEPTOR | - |
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