Full metadata record
DC Field | Value | Language |
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dc.citation.startPage | 118435 | - |
dc.citation.title | NEUROIMAGE | - |
dc.citation.volume | 241 | - |
dc.contributor.author | Han, Sohyun | - |
dc.contributor.author | Eun, Seulgi | - |
dc.contributor.author | Cho, Hyungjoon | - |
dc.contributor.author | Uludac, Kamil | - |
dc.contributor.author | Kim, Seong-Gi | - |
dc.date.accessioned | 2023-12-21T15:08:43Z | - |
dc.date.available | 2023-12-21T15:08:43Z | - |
dc.date.created | 2021-07-30 | - |
dc.date.issued | 2021-11 | - |
dc.description.abstract | Mapping mesoscopic cortical functional units such as columns or laminae is increasingly pursued by ultra-high field (UHF) functional magnetic resonance imaging (fMRI). The most popular approach for high-resolution fMRI is currently gradient-echo (GE) blood oxygenation level-dependent (BOLD) fMRI. However, its spatial accuracy is reduced due to its sensitivity to draining vessels, including pial veins, whereas spin-echo (SE) BOLD signal is expected to have higher spatial accuracy, albeit with lower sensitivity than the GE-BOLD signal. Here, we introduce a new double spin-echo (dSE) echo-planar imaging (EPI) method to improve the sensitivity of SE-BOLD contrast by averaging two spin-echoes using three radiofrequency pulses. Human fMRI experiments were performed with slices perpendicular to the central sulcus between motor and sensory cortices at 7 T during fist-clenching with touching. First, we evaluated the feasibility of single-shot dSE-EPI for BOLD fMRI with 1.5 mm isotropic resolution and found that dSE-BOLD fMRI has higher signal-to-noise ratio (SNR), temporal SNR (tSNR), and higher functional sensitivity than conventional SE-BOLD fMRI. Second, to investigate the laminar specificity of dSE-BOLD fMRI, we implemented a multi-shot approach to achieve 0.8-mm isotropic resolution with sliding-window reconstruction. Unlike GE-BOLD fMRI, the cortical profile of dSE-BOLD fMRI peaked at similar to 1.0 mm from the surface of the primary motor and sensory cortices, demonstrating an improvement of laminar specificity in humans over GE-BOLD fMRI. The proposed multi-shot dSE-EPI method is viable for high spatial resolution UHF-fMRI studies in the pursuit of resolving mesoscopic functional units. | - |
dc.identifier.bibliographicCitation | NEUROIMAGE, v.241, pp.118435 | - |
dc.identifier.doi | 10.1016/j.neuroimage.2021.118435 | - |
dc.identifier.issn | 1053-8119 | - |
dc.identifier.scopusid | 2-s2.0-85111493805 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/53366 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1053811921007102?via%3Dihub | - |
dc.identifier.wosid | 000693400400006 | - |
dc.language | 영어 | - |
dc.publisher | Academic Press | - |
dc.title | Improvement of sensitivity and specificity for laminar BOLD fMRI with double spin-echo EPI in humans at 7 T | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | NeurosciencesNeuroimagingRadiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalResearchArea | Neurosciences & NeurologyRadiology, Nuclear Medicine & Medical Imaging | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | High resolution fMRISpin-echo BOLDUltra-high fieldLayer specificity | - |
dc.subject.keywordPlus | CEREBRAL BLOOD-VOLUMEOCULAR DOMINANCE COLUMNSGRADIENT-ECHOHUMAN BRAINHIGH-FIELDMAGNETIC-SUSCEPTIBILITYSPATIAL-RESOLUTIONFUNCTIONAL MRICONTRAST SENSITIVITYSIGNAL CHANGES | - |
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