Full metadata record
DC Field | Value | Language |
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dc.citation.number | 10 | - |
dc.citation.startPage | e4570 | - |
dc.citation.title | NMR IN BIOMEDICINE | - |
dc.citation.volume | 34 | - |
dc.contributor.author | Jin, Seokha | - |
dc.contributor.author | Cho, Hyung Joon | - |
dc.date.accessioned | 2023-12-21T15:12:56Z | - |
dc.date.available | 2023-12-21T15:12:56Z | - |
dc.date.created | 2021-06-20 | - |
dc.date.issued | 2021-10 | - |
dc.description.abstract | Pharmacokinetic K-2 mapping from dynamic susceptibility contrast (DSC)-MRI can be a sensitive technique for evaluating the vascular permeability of the subtly damaged blood-brain barrier (BBB) in ischemic regions. However, the K-2 values of ischemic lesions depend upon the selection of the intact BBB reference region. As previous observations suggest that the Delta R-2* curve of pre-loaded DSC-MRI is not significantly affected by the extravasation of contrast agent, dual DSC-MRI acquisitions can be performed to derive the BBB leakage index from the voxel-wise reference input function for ischemic regions. This study aims to demonstrate the robustness of such model-free leakage index estimation in ischemic brains. By configuring the relationship between dual Delta R-2* curves of the intact contralateral brain, the deviation of the measured Delta R-2* curve from the unloaded DSC-MRI with respect to the non-deviated Delta R-2* curve in the pre-loaded DSC-MRI can be quantified as the BBB leakage index. Such model-free leakage index values from rats with transient middle carotid artery occlusion (tMCAO) (n = 17) and normal controls (n = 3) were evaluated and compared with conventional K-2 values with multiple reference regions. Inter-subject leakage index values were also compared with the corresponding Delta T-1 map. Evans-blue-stained images were used to validate the leakage index. For the tMCAO group, leakage index values correlated well with Delta T-1 (Pearson's r = 0.828). The hyperintense area on the leakage index map matched well with the corresponding Evans-blue-stained area (Dice correlation = 0.626). The slopes of the scatter-plot from the leakage index (0.97-1.00) were observed to be more robust against changes in the reference region than those from conventional K-2 values (0.94-1.07). In a subtly damaged BBB tMCAO model, model-free evaluation of vascular permeability using dual DSC-MRIs would provide a consistent measure of inter-subject vascular permeability. | - |
dc.identifier.bibliographicCitation | NMR IN BIOMEDICINE, v.34, no.10, pp.e4570 | - |
dc.identifier.doi | 10.1002/nbm.4570 | - |
dc.identifier.issn | 0952-3480 | - |
dc.identifier.scopusid | 2-s2.0-85107875241 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/53111 | - |
dc.identifier.url | https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/nbm.4570 | - |
dc.identifier.wosid | 000661509500001 | - |
dc.language | 영어 | - |
dc.publisher | WILEY | - |
dc.title | Model-free leakage index estimation of the blood-brain barrier using dual dynamic susceptibility contrast MRI acquisition | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Biophysics; Radiology, Nuclear Medicine & Medical Imaging; Spectroscopy | - |
dc.relation.journalResearchArea | Biophysics; Radiology, Nuclear Medicine & Medical Imaging; Spectroscopy | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | DSC-MRI | - |
dc.subject.keywordAuthor | DCE-MRI | - |
dc.subject.keywordAuthor | Vascular permeability | - |
dc.subject.keywordAuthor | Ischemic stroke | - |
dc.subject.keywordAuthor | Blood Brain Barrier | - |
dc.subject.keywordPlus | HEMORRHAGIC TRANSFORMATION | - |
dc.subject.keywordPlus | THROMBOLYTIC THERAPY | - |
dc.subject.keywordPlus | MULTIPLE-SCLEROSIS | - |
dc.subject.keywordPlus | REPERFUSION INJURY | - |
dc.subject.keywordPlus | ISCHEMIC-STROKE | - |
dc.subject.keywordPlus | TUMOR GRADE | - |
dc.subject.keywordPlus | TRACER | - |
dc.subject.keywordPlus | VOLUME | - |
dc.subject.keywordPlus | PERMEABILITY | - |
dc.subject.keywordPlus | FLOW | - |
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