Full metadata record
DC Field | Value | Language |
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dc.citation.endPage | 633 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 628 | - |
dc.citation.title | BMB REPORTS | - |
dc.citation.volume | 53 | - |
dc.contributor.author | Kim, JuHwan | - |
dc.contributor.author | Jung, Euitaek | - |
dc.contributor.author | Ahn, Sung Shin | - |
dc.contributor.author | Yeo, Hyunjin | - |
dc.contributor.author | Lee, Jeong Yeon | - |
dc.contributor.author | Seo, Jeong Kon | - |
dc.contributor.author | Lee, Young Han | - |
dc.contributor.author | Shin, Soon Young | - |
dc.date.accessioned | 2023-12-21T16:37:26Z | - |
dc.date.available | 2023-12-21T16:37:26Z | - |
dc.date.created | 2021-04-28 | - |
dc.date.issued | 2020-12 | - |
dc.description.abstract | WNT11 is a member of the non-canonical Wnt family and plays a crucial role in tumor progression. However, the regulatory mechanisms underlying WNT11 expression are unclear. Tumor necrosis factor-alpha (TNF alpha) is a major inflammatory cytokine produced in the tumor microenvironment and contributes to processes associated with tumor progression, such as tumor invasion and metastasis. By using site-directed mutagenesis and introducing a serial deletion in the 5'-regulatory region of WNT11, we observed that TNF alpha activates the early growth response 1 (EGR1)-binding sequence (EBS) in the proximal region of WNT11 and that the transcription factor EGR1 is necessary for the TNF alpha-induced transcription of WNT11. EGR1 bound directly to the EBSs within the proximal 5'-regulatory region of WNT11 and ectopic expression of EGR1 stimulated WNT11 promoter activity, whereas the knockdown of EGR1 expression by RNA interference reduced TNF alpha-induced WNT11 expression in T47D breast cancer cells. We also observed that mitogen-activated protein kinases (MAPK), extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 kinase mediated TNF alpha-induced transcription of WNT11 via EGR1. Our results suggest that EGR1 directly targets WNT11 in response to TNF alpha stimulation in breast cancer cells. | - |
dc.identifier.bibliographicCitation | BMB REPORTS, v.53, no.12, pp.628 - 633 | - |
dc.identifier.doi | 10.5483/BMBRep.2020.53.12.052 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.scopusid | 2-s2.0-85096950416 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/52856 | - |
dc.identifier.url | https://www.bmbreports.org/journal/view.html?volume=53&number=12&spage=628 | - |
dc.identifier.wosid | 000604903900003 | - |
dc.language | 영어 | - |
dc.publisher | KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY | - |
dc.title | WNT11 is a direct target of early growth response protein 1 | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | 5&apos | - |
dc.subject.keywordAuthor | -regulatory region | - |
dc.subject.keywordAuthor | Early growth response 1 | - |
dc.subject.keywordAuthor | Mitogen-activated protein kinase | - |
dc.subject.keywordAuthor | Tumor necrosis factor alpha | - |
dc.subject.keywordAuthor | Wnt family member 11 | - |
dc.subject.keywordPlus | TUMOR-NECROSIS-FACTOR | - |
dc.subject.keywordPlus | RECEPTOR-ALPHA | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | EGR-1 | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | INVASION | - |
dc.subject.keywordPlus | CATENIN | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | CELLS | - |
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