There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 6005 | - |
dc.citation.number | 13 | - |
dc.citation.startPage | 6000 | - |
dc.citation.title | JOURNAL OF ORGANIC CHEMISTRY | - |
dc.citation.volume | 79 | - |
dc.contributor.author | Kang, Jung Hyun | - |
dc.contributor.author | Kim, Hee Jin | - |
dc.contributor.author | Kwon, Tae-Hyuk | - |
dc.contributor.author | Hong, Jong-In | - |
dc.date.accessioned | 2023-12-22T02:37:02Z | - |
dc.date.available | 2023-12-22T02:37:02Z | - |
dc.date.created | 2014-07-30 | - |
dc.date.issued | 2014-07 | - |
dc.description.abstract | A bis[(4,6-difluorophenyl)pyridinato-N,C2']iridium(III) picolinate (FIrpic) derivative coupled with bis(Zn2+-dipicolylamine) (ZnDPA) was developed as a sensor (1) for phosphorylated peptides, which are related to many cellular mechanisms. As a control, a fluorescent sensor (2) based on anthracene coupled to ZnDPA was also prepared. When the total negative charge on the phosphorylated peptides was changed to -2, -4, and -6, the emission intensity of sensor 1 gradually increased by factors of up to 7, 11, and 16, respectively. In contrast, there was little change in the emission intensity of sensor 1 upon the addition of a neutral phosphorylated peptide, non-phosphorylated peptides, or various anions such as CO3 2-, NO3 -, SO4 2-, phosphate, azide, and pyrophosphate. Furthermore, sensor 1 could be used to visually discriminate between phosphorylated peptides and adenosine triphosphate in aqueous solution under a UV-vis lamp, unlike fluorescent sensor 2. This enhanced luminance of phosphorescent sensor 1 upon binding to a phosphorylated peptide is attributed to a reduction in the repulsion between the Zn 2+ ions due to the phenoxy anion, its strong metal-to-ligand charge transfer character, and a reduction in self-quenching. | - |
dc.identifier.bibliographicCitation | JOURNAL OF ORGANIC CHEMISTRY, v.79, no.13, pp.6000 - 6005 | - |
dc.identifier.doi | 10.1021/jo5005263 | - |
dc.identifier.issn | 0022-3263 | - |
dc.identifier.scopusid | 2-s2.0-84903708377 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/5275 | - |
dc.identifier.url | https://pubs.acs.org/doi/10.1021/jo5005263 | - |
dc.identifier.wosid | 000338693300007 | - |
dc.language | 영어 | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Phosphorescent sensor for phosphorylated peptides based on an iridium complex | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | ENERGY-TRANSFER | - |
dc.subject.keywordPlus | MOLECULAR RECOGNITION | - |
dc.subject.keywordPlus | AQUEOUS-SOLUTION | - |
dc.subject.keywordPlus | PYROPHOSPHATE SENSOR | - |
dc.subject.keywordPlus | ARTIFICIAL RECEPTORS | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | CHEMOSENSOR | - |
dc.subject.keywordPlus | BIOLOGY | - |
dc.subject.keywordPlus | WATER | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.