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| DC Field | Value | Language |
|---|---|---|
| dc.citation.conferencePlace | KO | - |
| dc.citation.conferencePlace | Seoul, Korea | - |
| dc.citation.title | Asian-Pacific Society for Neurochemistry 4th Meeting | - |
| dc.contributor.author | Lee, YH | - |
| dc.contributor.author | Bae, SS | - |
| dc.contributor.author | Seo, JK | - |
| dc.contributor.author | Choi, I | - |
| dc.contributor.author | Ryu, SH | - |
| dc.contributor.author | Suh, Pann-Ghill | - |
| dc.date.accessioned | 2023-12-20T06:39:56Z | - |
| dc.date.available | 2023-12-20T06:39:56Z | - |
| dc.date.created | 2014-12-23 | - |
| dc.date.issued | 1998-06-24 | - |
| dc.description.abstract | Phospholipase C (PLC)-gamma1 plays a pivotal role in the signal transduction pathway mediated by growth factors. In this study, we found that neurite outgrowth of pheochromocytoma (PC12) cells was significantly induced by interleukin-6 (IL-6). Stimulation of PC12 cells with IL-6 led to tyrosine phosphorylation of PLC-gamma1 in a dose- and time-dependent manner. IL-6 stimulation also increased the hydrolysis of phosphatidylinositol 4,5-bisphosphate. Accumulation of total inositol phosphate as well as tyrosine phosphorylation of PLC-gamma1 was inhibited by the pretreatment of protein kinase inhibitors such as genistein and staurosporine. These results suggest that PLC-gamma1 may be involved in the signal transduction pathway of IL-6-induced PC12 cell differentiation | - |
| dc.identifier.bibliographicCitation | Asian-Pacific Society for Neurochemistry 4th Meeting | - |
| dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/52339 | - |
| dc.publisher | J. Neurochem. Suppl. 2, S38D, | - |
| dc.title | Interleukin-6-induced tyrosine phosphorylation of phospholipase C-gamma1 in PC12 cells | - |
| dc.type | Conference Paper | - |
| dc.date.conferenceDate | 1998-06-24 | - |
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