Full metadata record
DC Field | Value | Language |
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dc.citation.endPage | 301 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 295 | - |
dc.citation.title | MOLECULES AND CELLS | - |
dc.citation.volume | 37 | - |
dc.contributor.author | Park, Sangjin | - |
dc.contributor.author | Sonn, Jun Young | - |
dc.contributor.author | Oh, Yangkyun | - |
dc.contributor.author | Lim, Chunghun | - |
dc.contributor.author | Choe, Joonho | - |
dc.date.accessioned | 2023-12-22T02:43:45Z | - |
dc.date.available | 2023-12-22T02:43:45Z | - |
dc.date.created | 2014-06-19 | - |
dc.date.issued | 2014-04 | - |
dc.description.abstract | SIFamide receptor (SIFR) is a Drosophila G protein-coupled receptor for the neuropeptide SIFamide (SIFa). Although the sequence and spatial expression of SIFa are evolutionarily conserved among insect species, the physiological function of SIFa/SIFR signaling remains elusive. Here, we provide genetic evidence that SIFa and SIFR promote sleep in Drosophila. Either genetic ablation of SIFa-expressing neurons in the pars intercerebralis (PI) or pan-neuronal depletion of SIFa expression shortened baseline sleep and reduced sleep-bout length, suggesting that it caused sleep fragmentation. Consistently, RNA interference-mediated knockdown of SIFR expression caused short sleep phenotypes as observed in SIFa-ablated or depleted flies. Using a panel of neuron-specific Gal4 drivers, we further mapped SIFR effects to subsets of PI neurons. Taken together, these results reveal a novel physiological role of the neuropeptide SIFa/SIFR pathway to regulate sleep through sleep-promoting neural circuits in the PI of adult fly brains. | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, v.37, no.4, pp.295 - 301 | - |
dc.identifier.doi | 10.14348/molcells.2014.2371 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.scopusid | 2-s2.0-84901404010 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/4968 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84901404010 | - |
dc.identifier.wosid | 000342560000003 | - |
dc.language | 영어 | - |
dc.publisher | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY | - |
dc.title | SIFamide and SIFamide receptor define a novel neuropeptide signaling to promote sleep in Drosophila | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Cell Biology | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | Drosophila melanogaster | - |
dc.subject.keywordAuthor | Pars Intercerebralis | - |
dc.subject.keywordAuthor | sleep | - |
dc.subject.keywordAuthor | SIFamide | - |
dc.subject.keywordAuthor | SIFamide receptor | - |
dc.subject.keywordPlus | OCTOPAMINE | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | CONSOLIDATION | - |
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