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Author

Cho, Hyungjoon
Biomedical Imaging Science and Engineering Lab(BISE)
Research Interests
  • Imaging tumor microenvironments, susceptibility contrast based MR structural imaging, ultra fast acquisitions of dynamic MR, algorithm/Hardware development for magnetic particle imaging

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Ultrafast 3d spin-echo acquisition improves gadolinium-enhanced mri signal contrast enhancement

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Title
Ultrafast 3d spin-echo acquisition improves gadolinium-enhanced mri signal contrast enhancement
Author
Han, S.H.Cho, F.H.Song, Y.K.Paulsen, J.Song, Y.Q.Kim, Y.R.Kim, J.K.Cho, G.Cho, Hyungjoon
Keywords
DIAGNOSTIC MARKERS; MEDICAL IMAGING
Issue Date
201405
Publisher
NATURE PUBLISHING GROUP
Citation
SCIENTIFIC REPORTS, v.4, no., pp.1 - 8
Abstract
Long scan times of 3D volumetric MR acquisitions usually necessitate ultrafast in vivo gradient-echo acquisitions, which are intrinsically susceptible to magnetic field inhomogeneities. This is especially problematic for contrast-enhanced (CE)-MRI applications, where non-negligible T 2 & z.ast; effect of contrast agent deteriorates the positive signal contrast and limits the available range of MR acquisition parameters and injection doses. To overcome these shortcomings without degrading temporal resolution, ultrafast spin-echo acquisitions were implemented. Specifically, a multiplicative acceleration factor from multiple spin echoes (×32) and compressed sensing (CS) sampling (×8) allowed highly-accelerated 3D Multiple-Modulation- Multiple-Echo (MMME) acquisition. At the same time, the CE-MRI of kidney with Gd-DOTA showed significantly improved signal enhancement for CS-MMME acquisitions (×7) over that of corresponding FLASH acquisitions (×2). Increased positive contrast enhancement and highly accelerated acquisition of extended volume with reduced RF irradiations will be beneficial for oncological and nephrological applications, in which the accurate in vivo 3D quantification of contrast agent concentration is necessary with high temporal resolution.
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DOI
http://dx.doi.org/10.1038/srep05061
ISSN
2045-2322
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SLS_Journal Papers
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