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Author

Kwon, H. Moo
Inflammation and Kidney Disorder Lab
Research Interests
  • TonEBP, Obesity, Cancer, Chronic inflammatory diseases, Brain disorder, Kidney disorders, Genomic instability

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REGULATION OF RENAL-CELL ORGANIC OSMOLYTE TRANSPORT BY TONICITY

Cited 78 times inthomson ciCited 35 times inthomson ci
Title
REGULATION OF RENAL-CELL ORGANIC OSMOLYTE TRANSPORT BY TONICITY
Author
HANDLER, JSKwon, H. Moo
Keywords
betaine;  myo-inositol;  taurine
Issue Date
199312
Publisher
American Physiological Society
Citation
AMERICAN JOURNAL OF PHYSIOLOGY, v.265, no.6, pp.C1449 - C1455
Abstract
Madin-Darby canine kidney cells accumulate several nonperturbing organic osmolytes when cultured in a hypertonic medium. Myo-inositol, betaine, and taurine are accumulated secondary to an increase in uptake, the first coupled to sodium entry, the latter two coupled to sodium and chloride entry. The transport rates increase as the result of an increase in maximum velocity for each cotransporter, with peak activity 24 h after the increase in tonicity. The cDNA for each cotransporter has been cloned. Their sequences indicate that the myo-inositol cotransporter belongs to the gene family that includes the sodium-coupled glucose transporter (SGLT1); the betaine and taurine cotransporters belong to the gene family of sodium- and chloride-coupled transporters that are responsible for neuronal uptake of many neurotransmitters. Assays of mRNA abundance and nuclear run-on assays reveal that shifts in tonicity have a major effect on transcription of the genes for the sodium-myo inositol (SMIT) and sodium-chloride-betaine (BGT1) cotransporters. The ensuing increase in mRNA abundance for the two cotransporters and presumed increase in synthesis of the cotransporter proteins can explain the increase in transport activity in response to changes in tonicity.
URI
http://scholarworks.unist.ac.kr/handle/201301/4917
ISSN
0002-9513
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