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Author

Kwon, H. Moo
Inflammation and Kidney Disorder Lab
Research Interests
  • TonEBP, Obesity, Cancer, Chronic inflammatory diseases, Brain disorder, Kidney disorders, Genomic instability

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THE MAP KINASE CASCADE IS NOT ESSENTIAL FOR TRANSCRIPTIONAL STIMULATION OF OSMOLYTE TRANSPORTER GENES

Cited 60 times inthomson ciCited 58 times inthomson ci
Title
THE MAP KINASE CASCADE IS NOT ESSENTIAL FOR TRANSCRIPTIONAL STIMULATION OF OSMOLYTE TRANSPORTER GENES
Author
Kwon, H. MooITOH, TRIM, JSHANDLER, JS
Keywords
NA+
Issue Date
199508
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Citation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.213, no.3, pp.975 - 979
Abstract
Kidney derived MDCK cells are protected from the stress of hypertonicity by accumulating compatible osmolytes. Accumulation of the compatible osmolytes myo-inositol and betaine is driven by hypertonicity-induced stimulation of transcription of the genes coding for the myoinositol cotransporter and the betaine cotransporter. We tested the importance of the mitogen-activated protein kinase pathway in transcriptional activation of the genes for the two osmolytes cotransporters because this kinase pathway is rapidly activated when cells are exposed to hypertonicity and a mitogen-activated protein kinase pathway is essential for the osmo-protective transcriptional response of yeast to hypertonicity. Eliminating the activation of mitogen-activated protein kinase did not block the hypertonicity induced increase in accumulation of osmolyte transporter mRNA.
URI
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DOI
http://dx.doi.org/10.1006/bbrc.1995.2224
ISSN
0006-291X
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