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Author

Kwon, H. Moo
Inflammation and Kidney Disorder Lab
Research Interests
  • TonEBP, Obesity, Cancer, Chronic inflammatory diseases, Brain disorder, Kidney disorders, Genomic instability

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Transcriptional regulation by changes in tonicity

Cited 47 times inthomson ciCited 47 times inthomson ci
Title
Transcriptional regulation by changes in tonicity
Author
Handler, JSKwon, H. Moo
Keywords
Betaine; Calcineurin; Cyclosporine A; Myoinositol; Sorbitol; Taurine; TonEBP
Issue Date
200108
Publisher
NATURE PUBLISHING GROUP
Citation
KIDNEY INTERNATIONAL, v.60, no.2, pp.408 - 411
Abstract
Most organisms respond to a hypertonic environment by accumulating small organic solutes. In contrast to high concentrations of electrolytes, the small organic solutes do not perturb the activity of enzymes and other macromolecules within the cell. When the renal medulla becomes hypertonic during antidiuresis, multiple signaling pathways are activated. Here. we: review the role of tonicity responsive enhancers (TonE) binding protein (TonEBP), a transcription factor activated in hypertonic cells. The activation of TonEBP by hypertonicity results from its translocation to the nucleus as well as an increase in TonEBP mRNA and protein. TonEBP may have a role beyond the response to tonicity since it is highly expressed in activated lymphocytes and in developing tissues.
URI
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DOI
http://dx.doi.org/10.1046/j.1523-1755.2001.060002408.x
ISSN
0085-2538
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