Transcriptional regulation by changes in tonicity
Cited 47 times inCited 47 times in
- Transcriptional regulation by changes in tonicity
- Handler, JS; Kwon, H. Moo
- Betaine; Calcineurin; Cyclosporine A; Myoinositol; Sorbitol; Taurine; TonEBP
- Issue Date
- NATURE PUBLISHING GROUP
- KIDNEY INTERNATIONAL, v.60, no.2, pp.408 - 411
- Most organisms respond to a hypertonic environment by accumulating small organic solutes. In contrast to high concentrations of electrolytes, the small organic solutes do not perturb the activity of enzymes and other macromolecules within the cell. When the renal medulla becomes hypertonic during antidiuresis, multiple signaling pathways are activated. Here. we: review the role of tonicity responsive enhancers (TonE) binding protein (TonEBP), a transcription factor activated in hypertonic cells. The activation of TonEBP by hypertonicity results from its translocation to the nucleus as well as an increase in TonEBP mRNA and protein. TonEBP may have a role beyond the response to tonicity since it is highly expressed in activated lymphocytes and in developing tissues.
- ; Go to Link
Appears in Collections:
- SLS_Journal Papers
can give you direct access to the published full text of this article. (UNISTARs only)
Show full item record
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.