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Author

Kwon, H. Moo
Inflammation and Kidney Disorder Lab
Research Interests
  • TonEBP, Obesity, Cancer, Chronic inflammatory diseases, Brain disorder, Kidney disorders, Genomic instability

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Urea promotes TonEBP expression and cellular adaptation in extreme hypertonicity

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Title
Urea promotes TonEBP expression and cellular adaptation in extreme hypertonicity
Author
Kwon, Min SeongNa, Ki YoungMoeckel, GilbertDo Lee, SangKwon, H. Moo
Keywords
Renal medulla; Urinary concentration; Organic osmolytes; HSP70; Aldose reductase
Issue Date
200911
Publisher
SPRINGER
Citation
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, v.459, no.1, pp.183 - 189
Abstract
The transcriptional activator TonEBP is a central regulator of osmolality in the renal medulla and whole body water homeostasis. In order to understand the regulation of TonEBP in the renal medulla, we examined MDCK cells, a kidney-derived epithelial cell line, under conditions mimicking the renal medulla. Moderate changes in ambient tonicity, which was tolerated without prior adaptation, displayed lasting effects on TonEBP in bidirectional manner-stimulated by hypertonicity and inhibited by hypotonicity. TonEBP expression was further enhanced by extreme hypertonicity observed in the inner medullae of antidiuretic animals. Urea stimulated TonEBP expression and promoted cellular proliferation under the conditions of extreme hypertonicity. On the other hand, the TonEBP activity was negatively modulated under these conditions presumably to temper the highly abundant TonEBP. We conclude that urea is critical to the cellular adaptation to extreme hypertonicity and the high level of TonEBP expression in the inner medulla.
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DOI
http://dx.doi.org/10.1007/s00424-009-0696-5
ISSN
0031-6768
Appears in Collections:
SLS_Journal Papers

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