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권혁무

Kwon, Hyug Moo
Immunometabolism and Cancer Lab.
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dc.citation.endPage C1288 -
dc.citation.number 6 -
dc.citation.startPage C1282 -
dc.citation.title AMERICAN JOURNAL OF PHYSIOLOGY -
dc.citation.volume 263 -
dc.contributor.author PAREDES, A -
dc.contributor.author MCMANUS, M -
dc.contributor.author Kwon, H. Moo -
dc.contributor.author STRANGE, K -
dc.date.accessioned 2023-12-22T13:07:01Z -
dc.date.available 2023-12-22T13:07:01Z -
dc.date.created 2014-06-02 -
dc.date.issued 1992-12 -
dc.description.abstract During plasma hypertonicity brain volume is regulated acutely by electrolyte uptake and chronically by accumulation of organic solutes such as inositol. Cultured rat C6 glioma cells, an astrocyte-like cell line, show a similar pattern of volume control. Volume regulatory accumulation of inositol requires external inositol, indicating that membrane transport plays a central role in this process. The inositol uptake pathway is Na+ dependent and exhibits Michaelis-Menten kinetics. Chronic hypertonic acclimation results in a twofold increase in the maximum velocity of the transporter without changing the K(m). Hypertonic stress also results in a 17-fold increase in transporter mRNA. Elevation of mRNA levels precedes activation of the transporter by 4-6 h, suggesting that increased inositol uptake is mediated by synthesis and membrane insertion of new transport proteins. Reacclimation of hypertonic cells to isotonicity causes a rapid reduction of transporter mRNA levels to control levels within 4 h. In contrast, downregulation of transport activity does not begin until between 10 and 24 h after reexposure to isotonicity. -
dc.identifier.bibliographicCitation AMERICAN JOURNAL OF PHYSIOLOGY, v.263, no.6, pp.C1282 - C1288 -
dc.identifier.issn 0002-9513 -
dc.identifier.scopusid 2-s2.0-0027043129 -
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/4863 -
dc.identifier.url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0027043129 -
dc.identifier.wosid A1992KF37500019 -
dc.language 영어 -
dc.publisher American Physiological Society -
dc.title OSMOREGULATION OF NA+-INOSITOL COTRANSPORTER ACTIVITY AND MESSENGER-RNA LEVELS IN BRAIN GLIAL-CELLS -
dc.type Article -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -

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