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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | C1288 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | C1282 | - |
dc.citation.title | AMERICAN JOURNAL OF PHYSIOLOGY | - |
dc.citation.volume | 263 | - |
dc.contributor.author | PAREDES, A | - |
dc.contributor.author | MCMANUS, M | - |
dc.contributor.author | Kwon, H. Moo | - |
dc.contributor.author | STRANGE, K | - |
dc.date.accessioned | 2023-12-22T13:07:01Z | - |
dc.date.available | 2023-12-22T13:07:01Z | - |
dc.date.created | 2014-06-02 | - |
dc.date.issued | 1992-12 | - |
dc.description.abstract | During plasma hypertonicity brain volume is regulated acutely by electrolyte uptake and chronically by accumulation of organic solutes such as inositol. Cultured rat C6 glioma cells, an astrocyte-like cell line, show a similar pattern of volume control. Volume regulatory accumulation of inositol requires external inositol, indicating that membrane transport plays a central role in this process. The inositol uptake pathway is Na+ dependent and exhibits Michaelis-Menten kinetics. Chronic hypertonic acclimation results in a twofold increase in the maximum velocity of the transporter without changing the K(m). Hypertonic stress also results in a 17-fold increase in transporter mRNA. Elevation of mRNA levels precedes activation of the transporter by 4-6 h, suggesting that increased inositol uptake is mediated by synthesis and membrane insertion of new transport proteins. Reacclimation of hypertonic cells to isotonicity causes a rapid reduction of transporter mRNA levels to control levels within 4 h. In contrast, downregulation of transport activity does not begin until between 10 and 24 h after reexposure to isotonicity. | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF PHYSIOLOGY, v.263, no.6, pp.C1282 - C1288 | - |
dc.identifier.issn | 0002-9513 | - |
dc.identifier.scopusid | 2-s2.0-0027043129 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/4863 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0027043129 | - |
dc.identifier.wosid | A1992KF37500019 | - |
dc.language | 영어 | - |
dc.publisher | American Physiological Society | - |
dc.title | OSMOREGULATION OF NA+-INOSITOL COTRANSPORTER ACTIVITY AND MESSENGER-RNA LEVELS IN BRAIN GLIAL-CELLS | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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