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Kwon, H. Moo
Inflammation and Kidney Disorder Lab
Research Interests
  • TonEBP, Obesity, Cancer, Chronic inflammatory diseases, Brain disorder, Kidney disorders, Genomic instability

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Mouse TonEBP-NFAT5: expression in early development and alternative splicing

Cited 42 times inthomson ciCited 41 times inthomson ci
Title
Mouse TonEBP-NFAT5: expression in early development and alternative splicing
Author
Maouyo, DKim, JYLee, SDWu, YHWoo, SKKwon, H. Moo
Keywords
organic/compatible osmolytes; hypertonicity; transcription factor; tonicity-responsive enhancer binding protein; nuclear factor of activated T cell family
Issue Date
200205
Publisher
AMER PHYSIOLOGICAL SOC
Citation
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, v.282, no.5, pp.F802 - F809
Abstract
Tonicity-responsive enhancer binding protein (TonEBP)-nuclear factor of activated T cell family 5 is a DNA binding protein that plays a key role in the response of cells to hypertonicity. However, TonEBP is expressed and active in tissues that are in an isotonic milieu. To explore the biological role of TonEBP, we cloned mouse TonEBP that shares 92% of amino acids with the human counterpart. TonEBP is expressed in embryonic stem cells and throughout the stages of fetal development. Immunohistochemical analysis shows expression of TonEBP in most, if not all, developing tissues, including the brain, colon, heart, muscle, and eyes. Widespread alternative splicing in exons 2-4 was detected throughout development and in different adult tissues. As a result, four different polypeptides are produced with different lengths at the NH(2) terminus. Two of the isoforms differ in their ability to stimulate transcription. In conclusion, the presence of TonEBP mRNA during mouse embryogenesis suggests that TonEBP functions at all stages of mouse development, as well as in isotonic adult tissues.
URI
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DOI
http://dx.doi.org/10.1152/ajprenal.00123.2001
ISSN
1931-857X
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