Osmotically-induced genes are controlled by the transcription factor TonEBP in cultured cardiomyocytes
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- Osmotically-induced genes are controlled by the transcription factor TonEBP in cultured cardiomyocytes
- Navarro, Paola; Chiong, Mario; Volkwein, Karen; Moraga, Francisco; Ocaranza, Maria Paz; Jalil, Jorge E.; Lim, Sun Woo; Kim, Jeong-Ah; Kwon, H. Moo; Lavandero, Sergio
- TonEBP; osmotic stress; tonicity; gene regulation; aldose reductase; cardiomyocytes; heart
- Issue Date
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.372, no.2, pp.326 - 330
- Changes in cardiac osmolarity occur in myocardial infarction. Osmoregulatory mechanism may, therefore, play a Crucial role in cardiomyocyte survival. Tonicity-responsive enhancer binding protein (TonEBP) is a key transcription factor participating in the adaptation of cells to increases in tonicity. However, it is unknown whether cardiac TonEBP is activated by tonicity. Hypertonicity activated transcriptional activity of TonEBP, increased the amounts of both TonEBP mRNA and protein, and induced both the mRNA and protein of TonEBP target genes (aldose reductase and heat shock protein-70). Hypotonicity decreased the amount of TonEBP protein indicating bidirectional osmoregulation of this transcription factor. Adenoviral expression of a dominant negative TonEBP suppressed the hypertonicity-dependent increase of aldose reductase protein. These results indicated that TonEBP controls osmoregulatory mechanisms in cardiomyocytes.
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