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Kwon, H. Moo
Inflammation and Kidney Disorder Lab
Research Interests
  • TonEBP, Obesity, Cancer, Chronic inflammatory diseases, Brain disorder, Kidney disorders, Genomic instability

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Identification of the second tonicity-responsive enhancer for the betaine transporter (BGT1) gene

Cited 38 times inthomson ciCited 34 times inthomson ci
Title
Identification of the second tonicity-responsive enhancer for the betaine transporter (BGT1) gene
Author
Miyakawa, HRim, JSHandler, JSKwon, H. Moo
Keywords
tonicity-responsive enhancer; betaine transporter; compatible osmolyte
Issue Date
199909
Publisher
Elsevier BV
Citation
BIOCHIMICA ET BIOPHYSICA ACTA - GENE STRUCTURE AND EXPRESSION, v.1446, no.3, pp.359 - 364
Abstract
When certain cells are exposed to a hypertonic solution, transcription of the BGT1 gene is markedly increased. The ensuing rise in betaine transport leads to cellular accumulation of betaine that protects the cells from the stress of hypertonicity. We have previously identified a tonicity-responsive enhancer (TonE1) in the 5' flanking region of the BGT1 gene. It was recognized, however, that full activation of transcription requires additional sequence upstream from the TonE1. Now we report that there is another TonE (named TonE2) 72 base pairs upstream from the TonE1. TonE1 and TonE2 act synergistically to stimulate transcription of BGT1 in response to hypertonicity.
URI
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DOI
http://dx.doi.org/10.1016/S0167-4781(99)00122-0
ISSN
0167-4781
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