Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.number | 10 | - |
dc.citation.startPage | 2822 | - |
dc.citation.title | CANCERS | - |
dc.citation.volume | 12 | - |
dc.contributor.author | Park, Juhee | - |
dc.contributor.author | Lee, Chaeeun | - |
dc.contributor.author | Eom, Jung Seop | - |
dc.contributor.author | Kim, Mi-Hyun | - |
dc.contributor.author | Cho, Yoon-Kyoung | - |
dc.date.accessioned | 2023-12-21T17:07:05Z | - |
dc.date.available | 2023-12-21T17:07:05Z | - |
dc.date.created | 2020-10-13 | - |
dc.date.issued | 2020-09 | - |
dc.description.abstract | The detection of epidermal growth factor receptor (EGFR) mutation, based on tissue biopsy samples, provides a valuable guideline for the prognosis and precision medicine in patients with lung cancer. In this study, we aimed to examine minimally invasive bronchial washing (BW)-derived extracellular vesicles (EVs) for EGFR mutation analysis in patients with lung cancer. A lab-on-a-disc equipped with a filter with 20-nm pore diameter, Exo-Disc, was used to enrich EVs in BW samples. The overall detection sensitivity of EGFR mutations in 55 BW-derived samples was 89.7% and 31.0% for EV-derived DNA (EV-DNA) and EV-excluded cell free-DNA (EV-X-cfDNA), respectively, with 100% specificity. The detection rate of T790M in 13 matched samples was 61.5%, 10.0%, and 30.8% from BW-derived EV-DNA, plasma-derived cfDNA, and tissue samples, respectively. The acquisition of T790M resistance mutation was detected earlier in BW-derived EVs than plasma or tissue samples. The longitudinal analysis of BW-derived EVs showed excellent correlation with the disease progression measured by CT images. The EGFR mutations can be readily detected in BW-derived EVs, which demonstrates their clinical potential as a liquid-biopsy sample that may aid precise management, including assessment of the treatment response and drug resistance in patients with lung cancer. | - |
dc.identifier.bibliographicCitation | CANCERS, v.12, no.10, pp.2822 | - |
dc.identifier.doi | 10.3390/cancers12102822 | - |
dc.identifier.issn | 2072-6694 | - |
dc.identifier.scopusid | 2-s2.0-85091837575 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/48292 | - |
dc.identifier.url | https://www.mdpi.com/2072-6694/12/10/2822 | - |
dc.identifier.wosid | 000582657600001 | - |
dc.language | 영어 | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.title | Detection of EGFR Mutations Using Bronchial Washing-Derived Extracellular Vesicles in Patients with Non-Small-Cell Lung Carcinoma | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalResearchArea | Oncology | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | lung cancer | - |
dc.subject.keywordAuthor | liquid biopsy | - |
dc.subject.keywordAuthor | bronchial washing (BW) | - |
dc.subject.keywordAuthor | extracellular vesicles | - |
dc.subject.keywordAuthor | EGFR | - |
dc.subject.keywordAuthor | T790M | - |
dc.subject.keywordPlus | ACQUIRED-RESISTANCE | - |
dc.subject.keywordPlus | LIQUID BIOPSIES | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordPlus | TECHNOLOGIES | - |
dc.subject.keywordPlus | SPECIMENS | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | CYTOLOGY | - |
dc.subject.keywordPlus | THERAPY | - |
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