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Author

Kwon, H. Moo
Inflammation and Kidney Disorder Lab
Research Interests
  • TonEBP, Obesity, Cancer, Chronic inflammatory diseases, Brain disorder, Kidney disorders, Genomic instability

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Hypertonicity-induced phosphorylation and nuclear localization of the transcription factor TonEBP

Cited 82 times inthomson ciCited 79 times inthomson ci
Title
Hypertonicity-induced phosphorylation and nuclear localization of the transcription factor TonEBP
Author
Dahl, SCHandler, JSKwon, H. Moo
Keywords
aldose reductase; organic osmolytes; sodium-chloride-betaine/gamma-aminobutyric acid cotransporter; sodium/myo-inositol cotransporter; NFAT5
Issue Date
200102
Publisher
AMER PHYSIOLOGICAL SOC
Citation
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, v.280, no.2, pp.C248 - C253
Abstract
The accumulation of compatible osmolytes during osmotic stress is observed in virtually all organisms. In mammals, the hypertonicity-induced expression of osmolyte transporters and synthetic enzymes is conferred by the presence of upstream tonicity-responsive enhancer (TonE) sequences. Recently, we described the cloning and initial characterization of TonE-binding protein (TonEBP), a transcription factor that translocates to the nucleus and associates with TonE sequences in a tonicity-dependent manner. We now report that hypertonicity induces an increase in TonEBP phosphorylation that temporally correlates with increased nuclear localization of the molecule. TonEBP phosphorylation is not affected by a number of kinase inhibitors, including the p38 inhibitor SB-203580. In addition, in vitro binding assays show that the association of TonEBP with TonE sequences is not affected by phosphorylation. Thus TonEBP phosphorylation is an early step in the response of cells to hypertonicity and may be required for nuclear import or retention.
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ISSN
0363-6143
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