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Author

Kwon, H. Moo
Inflammation and Kidney Disorder Lab
Research Interests
  • TonEBP, Obesity, Cancer, Chronic inflammatory diseases, Brain disorder, Kidney disorders, Genomic instability

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Interstitial tonicity controls TonEBP expression in the renal medulla

Cited 15 times inthomson ciCited 13 times inthomson ci
Title
Interstitial tonicity controls TonEBP expression in the renal medulla
Author
Sheen, Mee RKim, Jeong-AhLim, Sun WJung, Ju-YHan, Ki-HJeon, Un S(Park, Soo-HKim, JinKwon, H. Moo
Keywords
aldose reductase; aldosterone; furosemide; HSP70; vasopressin; water diuresis
Issue Date
200903
Publisher
NATURE PUBLISHING GROUP
Citation
KIDNEY INTERNATIONAL, v.75, no.5, pp.518 - 525
Abstract
Cells in the hyperosmotic kidney medulla, express a transcriptional activator termed tonicity responsive enhancer binding protein (TonEBP). Genes targeted by TonEBP protect kidney cells from the deleterious effects of hyperosmolality by inducing the expression of organic osmolytes and molecular chaperones, and other genes that mediate urine concentration such as aquaporin-2 and urea transporters. We tested here the effect of hypertonicity and hyperosmotic salt in the renal medullary interstitium on the expression TonEBP. When massive water diuresis was induced in rats the medullary sodium concentrations did not change, neither did TonEBP expression. In these animals the medullary tonicity was unchanged despite the production of dilute urine. On the other hand, treatment with the loop diurectic furosemide resulted in a dose-dependent decrease in the medullary sodium concentration causing a reduction in interstitial tonicity. Here, TonEBP expression was blunted in the outer and inner medulla which was due, in part, to decreased mRNA abundance. As expected, the expression of TonEBP target genes in the renal medulla also decreased in response to furosemide. Hence TonEBP expression in the renal medulla is stimulated by interstitial hypertonicity.
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DOI
http://dx.doi.org/10.1038/ki.2008.601
ISSN
0085-2538
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