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Kwon, H. Moo
Inflammation and Kidney Disorder Lab
Research Interests
  • TonEBP, Obesity, Cancer, Chronic inflammatory diseases, Brain disorder, Kidney disorders, Genomic instability

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Hypertonic Stress in the Kidney: A Necessary Evil

Cited 21 times inthomson ciCited 17 times inthomson ci
Title
Hypertonic Stress in the Kidney: A Necessary Evil
Author
Kwon, Min SeongLim, Sun WooKwon, H. Moo
Keywords
ENHANCER-BINDING PROTEIN; TONEBP/NFAT5 TRANSCRIPTIONAL ACTIVATOR; ACUTE SYSTEMIC HYPERTONICITY; RENAL COLLECTING DUCT; GENE-EXPRESSION; OSMOTIC-STRESS; STIMULATES TRANSCRIPTION; BARTTERS-SYNDROME; ALDOSE REDUCTASE; BRATTLEBORO RATS
Issue Date
200906
Publisher
AMER PHYSIOLOGICAL SOC
Citation
PHYSIOLOGY, v.24, no.3, pp.186 - 191
Abstract
The interstitium of the renal medulla is hypertonic, imposing deleterious effects on local cells. At the same time, the hypertonicity provides osmotic gradient for water reabsorption and is a local signal for tissue-specific gene expression and differentiation of the renal medulla, which is a critical organ for water homeostasis.
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DOI
http://dx.doi.org/10.1152/physiol.00005.2009
ISSN
1548-9213
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