Characterization and capacitive modeling of target concentration-dependent subthreshold swing in silicon nanoribbon biosensors
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- Characterization and capacitive modeling of target concentration-dependent subthreshold swing in silicon nanoribbon biosensors
- Lee, Won Hee; Lee, Jin-Moo; Uhm, Mihee; Lee, Jieun; Kim, Kyung Rok; Choi, Sung-Jin; Kim, Dong Myong; Jeong, Yong-Joo; Kim, Dae Hwan
- biosensor; Silicon nanowire FET; streptavidin-biotin; subthreshold swing
- Issue Date
- IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
- IEEE ELECTRON DEVICE LETTERS, v.35, no.5, pp.587 - 589
- The effect of streptavidin concentration as a target molecule on the subthreshold swing (SS) of biotin-functionalized silicon nanoribbon sensors was investigated for a configuration of field effect transistors. The increasing concentration of conjugated target molecules was modeled as a degradation of the coupling capacitance between the electrolyte and the sensor surface. A binding factor for the ratio of conjugation between targets and receptors was modeled as a coupled capacitance and experimentally determined to be from 0.65 (streptavidin at 1 pM) to 1 (1 nM). This result suggests that SS is potentially a good indicator of the target concentration.
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