File Download

There are no files associated with this item.

  • Find it @ UNIST can give you direct access to the published full text of this article. (UNISTARs only)
Related Researcher

권혁무

Kwon, Hyug Moo
Immunometabolism and Cancer Lab.
Read More

Views & Downloads

Detailed Information

Cited time in webofscience Cited time in scopus
Metadata Downloads

Full metadata record

DC Field Value Language
dc.citation.endPage 247 -
dc.citation.number 1-2 -
dc.citation.startPage 241 -
dc.citation.title ACTA PHYSIOLOGICA -
dc.citation.volume 187 -
dc.contributor.author Jeon, US -
dc.contributor.author Kim, JA -
dc.contributor.author Sheen, MR -
dc.contributor.author Kwon, H. Moo -
dc.date.accessioned 2023-12-22T10:06:51Z -
dc.date.available 2023-12-22T10:06:51Z -
dc.date.created 2014-05-23 -
dc.date.issued 2006-05 -
dc.description.abstract TonEBP stimulates genes whose products drive cellular accumulation of organic osmolytes and HSP70, which protect cells from the deleterious effects of hypertonicity and urea, respectively. Mice deficient in the TonEBP gene display severe atrophy of the renal medulla because cells failed to adapt to the hyperosmolality. Emerging data suggest that TonEBP plays a key role in the urinary concentrating mechanism by stimulating the UT-A urea transporters and possibly AQP2 water channel. Thus, TonEBP is an essential regulator in the urinary concentrating mechanism. Studies on structural basis of TonEBP function have revealed the structure of the DNA binding domain, and defined the transactivation domains. Molecular mechanisms underlying the nucleocytoplasmic trafficking, transactivation, and phosphorylation in response to changes in tonicity need to be understood in molecular detail. Such knowledge is needed for the identification of the sensor that detects changes in ambient tonicity and signals to TonEBP. -
dc.identifier.bibliographicCitation ACTA PHYSIOLOGICA, v.187, no.1-2, pp.241 - 247 -
dc.identifier.doi 10.1111/j.1748-1716.2006.01551.x -
dc.identifier.issn 1748-1708 -
dc.identifier.scopusid 2-s2.0-33744822996 -
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/4741 -
dc.identifier.url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33744822996 -
dc.identifier.wosid 000237738800025 -
dc.language 영어 -
dc.publisher WILEY-BLACKWELL -
dc.title How tonicity regulates genes: story of TonEBP transcriptional activator -
dc.type Article -
dc.subject.keywordAuthor AQP2 -
dc.subject.keywordAuthor NFAT5 -
dc.subject.keywordAuthor renal medulla -
dc.subject.keywordAuthor urea transporters -
dc.subject.keywordAuthor urinary concentration -
dc.subject.keywordPlus OSMOTIC-RESPONSE ELEMENT -
dc.subject.keywordPlus ENHANCER-BINDING PROTEIN -
dc.subject.keywordPlus DAMAGE-INDUCIBLE KINASE -
dc.subject.keywordPlus RENAL MEDULLARY CELLS -
dc.subject.keywordPlus CANINE KIDNEY-CELLS -
dc.subject.keywordPlus RNA HELICASE-A -
dc.subject.keywordPlus OSMOPROTECTIVE GENES -
dc.subject.keywordPlus STIMULATES TRANSCRIPTION -
dc.subject.keywordPlus NUCLEAR-LOCALIZATION -
dc.subject.keywordPlus RAT-KIDNEY -

qrcode

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.