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Kwon, H. Moo
Inflammation and Kidney Disorder Lab
Research Interests
  • TonEBP, Obesity, Cancer, Chronic inflammatory diseases, Brain disorder, Kidney disorders, Genomic instability

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CLONING OF THE CDNA FOR A NA+/MYO-INOSITOL COTRANSPORTER, A HYPERTONICITY STRESS PROTEIN

Cited 279 times inthomson ciCited 200 times inthomson ci
Title
CLONING OF THE CDNA FOR A NA+/MYO-INOSITOL COTRANSPORTER, A HYPERTONICITY STRESS PROTEIN
Author
Kwon, H. MooYAMAUCHI, AUCHIDA, SPRESTON, ASGARCIAPEREZ, ABURG, MBHANDLER, JS
Keywords
MYOINOSITOL TRANSPORT; NUCLEOTIDE-SEQUENCE; SYMPORT CARRIER; NA+/GLUCOSE; GLUCOSE; CELLS; GENE
Issue Date
199203
Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Citation
JOURNAL OF BIOLOGICAL CHEMISTRY, v.267, no.9, pp.6297 - 6301
Abstract
Kidney medullary cells in situ, as well as kidney-derived Madin-Darby canine kidney (MDCK) cells accumulate nonperturbing, small organic solutes (osmolytes), including myo-inositol, when bathed in hypertonic media. Accumulation of osmolytes balances the osmolality of extracellular fluid without raising intracellular salts that would perturb cellular functions. In hypertonic media, increased myo-inositol accumulation is the result of increased activity of a Na+/myo-inositol cotransporter. We have isolated a cDNA encoding a Na+/myo-inositol cotransporter from MDCK cells using expression in Xenopus oocytes. The cDNA sequence predicts a protein of 718 amino acids with a significant amino acid sequence similarity to the Na+/D-glucose cotransporters of absorbing epithelia. Transporter mRNA is present in kidney and brain and is markedly induced in MDCK cells by medium hypertonicity, demonstrating that adaptation to hypertonic stress involves up-regulation of transporter mRNA accumulation.
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ISSN
0021-9258
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