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Kwon, H. Moo
Inflammation and Kidney Disorder Lab
Research Interests
  • TonEBP, Obesity, Cancer, Chronic inflammatory diseases, Brain disorder, Kidney disorders, Genomic instability

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CELL-VOLUME REGULATED TRANSPORTERS OF COMPATIBLE OSMOLYTES

Cited 108 times inthomson ciCited 107 times inthomson ci
Title
CELL-VOLUME REGULATED TRANSPORTERS OF COMPATIBLE OSMOLYTES
Author
Kwon, H. MooHANDLER, JS
Keywords
RESISTANCE P-GLYCOPROTEIN; BRAIN GLIAL-CELLS; INOSITOL COTRANSPORTER; MDCK CELLS; CLONING; CHANNEL; EXPRESSION; ACTIVATION; PROTEIN; CALCIUM
Issue Date
199508
Publisher
CURRENT BIOLOGY LTD
Citation
CURRENT OPINION IN CELL BIOLOGY, v.7, no.4, pp.465 - 471
Abstract
Virtually all cells respond to hypertonicity by accumulating certain small organic solutes (compatible osmolytes) that, in contrast to intracellular ions, do not perturb macromolecular function. Several important compatible osmolytes are accumulated by coupled transport. Transcription of genes encoding these cotransporters is increased by hypertonicity and a tonicity-responsive enhancer element has been identified. When cells return to an iso-osmotic environment, osmolytes are rapidly lost through a pathway that current evidence indicates may be a volume-sensitive chloride channel.
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DOI
http://dx.doi.org/10.1016/0955-0674(95)80002-6
ISSN
0955-0674
Appears in Collections:
SLS_Journal Papers

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