CELL-VOLUME REGULATED TRANSPORTERS OF COMPATIBLE OSMOLYTES
Cited 108 times inCited 107 times in
- CELL-VOLUME REGULATED TRANSPORTERS OF COMPATIBLE OSMOLYTES
- Kwon, H. Moo; HANDLER, JS
- RESISTANCE P-GLYCOPROTEIN; BRAIN GLIAL-CELLS; INOSITOL COTRANSPORTER; MDCK CELLS; CLONING; CHANNEL; EXPRESSION; ACTIVATION; PROTEIN; CALCIUM
- Issue Date
- CURRENT BIOLOGY LTD
- CURRENT OPINION IN CELL BIOLOGY, v.7, no.4, pp.465 - 471
- Virtually all cells respond to hypertonicity by accumulating certain small organic solutes (compatible osmolytes) that, in contrast to intracellular ions, do not perturb macromolecular function. Several important compatible osmolytes are accumulated by coupled transport. Transcription of genes encoding these cotransporters is increased by hypertonicity and a tonicity-responsive enhancer element has been identified. When cells return to an iso-osmotic environment, osmolytes are rapidly lost through a pathway that current evidence indicates may be a volume-sensitive chloride channel.
- ; Go to Link
Appears in Collections:
- SLS_Journal Papers
can give you direct access to the published full text of this article. (UNISTARs only)
Show full item record
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.