File Download

There are no files associated with this item.

  • Find it @ UNIST can give you direct access to the published full text of this article. (UNISTARs only)
Related Researcher

권혁무

Kwon, Hyug Moo
Immunometabolism and Cancer Lab.
Read More

Views & Downloads

Detailed Information

Cited time in webofscience Cited time in scopus
Metadata Downloads

Full metadata record

DC Field Value Language
dc.citation.endPage 71 -
dc.citation.number 1 -
dc.citation.startPage 51 -
dc.citation.title NEUROSCIENCE -
dc.citation.volume 137 -
dc.contributor.author Maallem, S -
dc.contributor.author Mutin, M -
dc.contributor.author Kwon, H. Moo -
dc.contributor.author Tappaz, ML -
dc.date.accessioned 2023-12-22T10:09:49Z -
dc.date.available 2023-12-22T10:09:49Z -
dc.date.created 2014-05-22 -
dc.date.issued 2006 -
dc.description.abstract n a previous work performed on cerebral cortex and hippocampus we reported that tonicity-responsive enhancer binding protein (TonEBP), originally identified as a transactivator of osmoprotective genes involved in osmoadaptation of renal cells, was induced in neurons only, but to varying levels, following acute systemic hypertonicity. Whether or not this cellular specificity reflected a unique ability of neurons or a differential time course among brain cells for tonicity-induction of TonEBP was investigated throughout the brain in this study by subjecting the animals to prolonged systemic hypertonicity. In normal rats, TonEBP immunolabeling and TonEBP-mRNA in situ hybridization labeling showed a widespread, uneven and parallel distribution. TonEBP was expressed primarily in the cell nuclei of neurons, where it was heterogeneously distributed in a nucleoplasmic and a granular pool. In rats subjected to prolonged systemic hypertonicity, TonEBP labeling increased in the cell nuclei of neurons only. The tonicity-induced expression of TonEBP for a given cell group of neurons was rather uniform but varied greatly among neuronal cell groups and was positively correlated with the average size of the cell nuclei, as determined by quantitative analysis of digitized images. The detailed distribution of tonicity-induced expression of TonEBP is reported throughout the brain. In normal rats, a very minor proportion of non-neuronal cells, identified as a subset of astrocytes and possibly oligodendrocytes, showed faint nuclear immunolabeling, which however did not increase in hypertonic animals. Ependymocytes, capillary endothelial cells, and microglial cells showed no TonEBP labeling, even in hypertonic animals. Altogether our data indicate that neurons, albeit possibly to a varying extent, are the only brain cells able to use TonEBP-mediated processes for adaptation to a systemic hyperosmotic unbalance. -
dc.identifier.bibliographicCitation NEUROSCIENCE, v.137, no.1, pp.51 - 71 -
dc.identifier.doi 10.1016/j.neuroscience.2005.07.037 -
dc.identifier.issn 0306-4522 -
dc.identifier.scopusid 2-s2.0-29744448550 -
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/4706 -
dc.identifier.url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=29744448550 -
dc.identifier.wosid 000234761200008 -
dc.language 영어 -
dc.publisher PERGAMON-ELSEVIER SCIENCE LTD -
dc.title Differential cellular distribution of tonicity-induced expression of transcription factor TonEBP in the rat brain following prolonged systemic hypertonicity -
dc.type Article -
dc.description.journalRegisteredClass scopus -
dc.subject.keywordAuthor tonicity-responsive enhancer binding protein -
dc.subject.keywordAuthor TonEBP -
dc.subject.keywordAuthor cell volume regulation -
dc.subject.keywordAuthor cell osmoregulation -
dc.subject.keywordAuthor hyperosmolarity -
dc.subject.keywordAuthor osmoprotective genes -
dc.subject.keywordPlus ENHANCER-BINDING PROTEIN -
dc.subject.keywordPlus OSMOTIC RESPONSE ELEMENT -
dc.subject.keywordPlus CENTRAL-NERVOUS-SYSTEM -
dc.subject.keywordPlus GENE-EXPRESSION -
dc.subject.keywordPlus PRIMARY-CARE -
dc.subject.keywordPlus VOLUME -
dc.subject.keywordPlus CELLS -
dc.subject.keywordPlus HYPERNATREMIA -
dc.subject.keywordPlus TRANSPORTERS -
dc.subject.keywordPlus HYPONATREMIA -

qrcode

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.