BROWSE

Related Researcher

Author

Kwon, H. Moo
Inflammation and Kidney Disorder Lab
Research Interests
  • TonEBP, Obesity, Cancer, Chronic inflammatory diseases, Brain disorder, Kidney disorders, Genomic instability

ITEM VIEW & DOWNLOAD

Adaptation of kidney medulla to hypertonicity: Role of the transcription factor TonEBP

Cited 27 times inthomson ciCited 25 times inthomson ci
Title
Adaptation of kidney medulla to hypertonicity: Role of the transcription factor TonEBP
Author
Woo, SKKwon, H. Moo
Keywords
Kidney medulla;  NFAT5;  Osmolytes;  TonEBP
Issue Date
2002
Publisher
ELSEVIER ACADEMIC PRESS INC
Citation
INTERNATIONAL REVIEW OF CYTOLOGY-A SURVEY OF CELL BIOLOGY, v.215, no., pp.189 - 202
Abstract
The osmolality of the mammalian kidney medulla is very high. The high osmolality provides the driving force for water reabsorption and urinary concentration, key functions of the kidney for maintaining proper body fluid volume and blood pressure. Salt and urea are the major solutes in the renal medullary interstitium. Unfortunately, high salt (hypertonicity) causes DNA damage and cell death. In response, the renal medullary cells adapt to the hypertonicity by accumulating compatible osmolytes. A regulatory protein, tonicity-responsive enhancer binding protein (TonEBP), plays a central role in the accumulation of these compatible osmolytes by stimulating genes whose products either actively transport or synthesize the appropriate osmolytes. TonEBP is active under isotonic conditions. It responds to both an increase and a decrease in ambient tonicity, in opposite directions, which involves changes in its abundance and nucleocytoplasmic distribution. In the kidney medulla, however, nucleocytoplasmic distribution is the major site of control, under normal conditions of diuresis and antidiuresis.
URI
http://scholarworks.unist.ac.kr/handle/201301/4690
DOI
http://dx.doi.org/10.1016/S0074-7696(02)15009-1
ISSN
0074-7696
Appears in Collections:
SLS_Journal Papers
Files in This Item:
There are no files associated with this item.

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qr_code

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU