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A small molecule that displays marked reactivity toward copper-versus zinc-amyloid-β implicated in Alzheimer's disease
- Author(s)
- Savelieff, Masha G., Liu, Yuzhong, Senthamarai, Russell R. P., Korshavn, Kyle J., Lee, Hyuck Jin, Ramamoorthy, Ayyalusamy, Lim, Mi Hee
- Issued Date
- 2014-05
- Citation
- CHEMICAL COMMUNICATIONS, v.50, no.40, pp.5301 - 5303
- Abstract
- Alzheimer's disease (AD) is a complex, multifactorial, neurodegenerative disease that poses tremendous difficulties in pinpointing its precise etiology. A toolkit, which specifically targets and modulates suggested key players, may elucidate their roles in disease onset and progression. We report high-resolution insights on the activity of a small molecule (L2-NO) which exhibits reactivity toward Cu(II)-amyloid-β (Aβ) over Zn(II)-Aβ.
- Publisher
- ROYAL SOC CHEMISTRY
- ISSN
- 1359-7345
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