A small molecule that displays marked reactivity toward copper-versus zinc-amyloid-β implicated in Alzheimer's disease
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- A small molecule that displays marked reactivity toward copper-versus zinc-amyloid-β implicated in Alzheimer's disease
- Savelieff, Masha G.; Liu, Yuzhong; Senthamarai, Russell R. P.; Korshavn, Kyle J.; Lee, Hyuck Jin; Ramamoorthy, Ayyalusamy; Lim, Mi Hee
- Issue Date
- ROYAL SOC CHEMISTRY
- CHEMICAL COMMUNICATIONS, v.50, no.40, pp.5301 - 5303
- Alzheimer's disease (AD) is a complex, multifactorial, neurodegenerative disease that poses tremendous difficulties in pinpointing its precise etiology. A toolkit, which specifically targets and modulates suggested key players, may elucidate their roles in disease onset and progression. We report high-resolution insights on the activity of a small molecule (L2-NO) which exhibits reactivity toward Cu(II)-amyloid-β (Aβ) over Zn(II)-Aβ.
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