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Lim, Mi Hee
MetalloNeuroChemistry Lab (MNCL)
Research Interests
  • Neurodegenerative disease, small molecule design, network between metal, proteins, and ROS

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A small molecule that displays marked reactivity toward copper-versus zinc-amyloid-β implicated in Alzheimer's disease

Cited 3 times inthomson ciCited 2 times inthomson ci
Title
A small molecule that displays marked reactivity toward copper-versus zinc-amyloid-β implicated in Alzheimer's disease
Author
Savelieff, Masha G.Liu, YuzhongSenthamarai, Russell R. P.Korshavn, Kyle J.Lee, Hyuck JinRamamoorthy, AyyalusamyLim, Mi Hee
Issue Date
201405
Publisher
ROYAL SOC CHEMISTRY
Citation
CHEMICAL COMMUNICATIONS, v.50, no.40, pp.5301 - 5303
Abstract
Alzheimer's disease (AD) is a complex, multifactorial, neurodegenerative disease that poses tremendous difficulties in pinpointing its precise etiology. A toolkit, which specifically targets and modulates suggested key players, may elucidate their roles in disease onset and progression. We report high-resolution insights on the activity of a small molecule (L2-NO) which exhibits reactivity toward Cu(II)-amyloid-β (Aβ) over Zn(II)-Aβ.
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DOI
http://dx.doi.org/10.1039/c3cc48473d
ISSN
1359-7345
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