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Cho, Hyungjoon
Biomedical Imaging Science and Engineering Lab(BISE)
Research Interests
  • Imaging tumor microenvironments, susceptibility contrast based MR structural imaging, ultra fast acquisitions of dynamic MR, algorithm/Hardware development for magnetic particle imaging

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Response of the primary auditory and non-auditory cortices to acoustic stimulation: A manganese-enhanced MRI study

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Title
Response of the primary auditory and non-auditory cortices to acoustic stimulation: A manganese-enhanced MRI study
Author
Kim, HyungjunCho, JunghunKim, Young R.Song, YoungkyuChun, Song-ISuh, Ji-YeonKim, Jeong KonRyu, Yeon-HeeChoi, Sun-MiCho, HyungjoonCho, Gyunggoo
Keywords
RESONANCE-IMAGING MEMRI; MEDIAL GENICULATE-BODY; VISUAL-CORTEX; INFERIOR COLLICULUS; FUNCTIONAL-ACTIVITY; SOCIAL STRESS; RAT; PROJECTIONS; PATHWAY; ORGANIZATION
Issue Date
201403
Publisher
PUBLIC LIBRARY SCIENCE
Citation
PLOS ONE, v.9, no.3, pp.e90427 -
Abstract
Structural and functional features of various cerebral cortices have been extensively explored in neuroscience research. We used manganese-enhanced MRI, a non-invasive method for examining stimulus-dependent activity in the whole brain, to investigate the activity in the layers of primary cortices and sensory, such as auditory and olfactory, pathways under acoustic stimulation. Male Sprague-Dawley rats, either with or without exposure to auditory stimulation, were scanned before and 24-29 hour after systemic MnCl2 injection. Cortex linearization and layer-dependent signal extraction were subsequently performed for detecting layer-specific cortical activity. We found stimulus-dependent activity in the deep layers of the primary auditory cortex and the auditory pathways. The primary sensory and visual cortices also showed the enhanced activity, whereas the olfactory pathways did not. Further, we performed correlation analysis of the signal intensity ratios among different layers of each cortex, and compared the strength of correlations between with and without the auditory stimulation. In the primary auditory cortex, the correlation strength between left and right hemisphere showed a slight but not significant increase with the acoustic simulation, whereas, in the primary sensory and visual cortex, the correlation coefficients were significantly smaller. These results suggest the possibility that even though the primary auditory, sensory, and visual cortices showed enhanced activity to the auditory stimulation, these cortices had different associations for auditory processing in the brain network.
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DOI
http://dx.doi.org/10.1371/journal.pone.0090427
ISSN
1932-6203
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SLS_Journal Papers
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