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Author

Kim, Byeong-Su
Soft and Hybrid Nanomaterials Lab
Research Interests
  • Carbon materials, polymer, Layer-by-Layer (LbL) assembly, hyperbranched polymer, polyglycerol (PG), bio-applications

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Light-responsive micelles of spiropyran initiated hyperbranched polyglycerol for smart drug delivery

Cited 5 times inthomson ciCited 1 times inthomson ci
Title
Light-responsive micelles of spiropyran initiated hyperbranched polyglycerol for smart drug delivery
Author
Son, SuhyunShin, EeseulKim, Byeong-Su
Keywords
Critical micelle concentration (cmc); Fluorescence analysis; Hyperbranched polyglycerol; Hyperbranched polyglycerols; Photochromic molecules; Smart drug deliveries; Smart drug delivery systems; UV/ Vis spectroscopy
Issue Date
201402
Publisher
AMER CHEMICAL SOC
Citation
BIOMACROMOLECULES, v.15, no.2, pp.628 - 634
Abstract
Light-responsive polymeric micelles have emerged as site-specific and time-controlled systems for advanced drug delivery. Spiropyran (SP), a wellknown photochromic molecule, was used to initiate the ring-opening multibranching polymerization of glycidol to afford a series of hyperbranched polyglycerols (SP-hb-PG). The micelle assembly and disassembly were induced by an external light source owing to the reversible photoisomerization of hydrophobic SP to hydrophilic merocyanine (MC). Transmission electron microscopy, atomic force microscopy, UV/vis spectroscopy, and dynamic light scattering demonstrated the successful assembly and disassembly of SP-hb-PG micelles. In addition, the critical micelle concentration (CMC) was determined through the fluorescence analysis of pyrene to confirm the amphiphilicity of respective SP-hb-PG n(n = 15, 29, and 36) micelles, with CMC values ranging from 13 to 20 mg/L, which is correlated to the length of the polar polyglycerol backbone. Moreover, the superior biocompatibility of the prepared SP-hb-PG was evaluated using WI-38 cells and HeLa cells, suggesting the prospective applicability of the micelles in smart drug delivery systems.
URI
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DOI
http://dx.doi.org/10.1021/bm401670t
ISSN
1525-7797
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