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DC Field | Value | Language |
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dc.citation.endPage | 2339 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 2332 | - |
dc.citation.title | BIOMACROMOLECULES | - |
dc.citation.volume | 14 | - |
dc.contributor.author | Min, Junseon | - |
dc.contributor.author | Jung, Hoesu | - |
dc.contributor.author | Shin, Hyun-Hee | - |
dc.contributor.author | Cho, Gyunggoo | - |
dc.contributor.author | Cho, HyungJoon | - |
dc.contributor.author | Kang, Sebyung | - |
dc.date.accessioned | 2023-12-22T03:43:01Z | - |
dc.date.available | 2023-12-22T03:43:01Z | - |
dc.date.created | 2013-08-27 | - |
dc.date.issued | 2013-07 | - |
dc.description.abstract | P22 viral capsids and ferritin protein cages are utilized as templating macromolecules to conjugate Gd(III)-chelating agent complexes, and we systematically investigates the effects of the macromolecules' size and the conjugation positions of Gd(III)-chelating agents on the magnetic resonance (MR) relaxivities and the resulting image contrasts. The relaxivity values of the Gd(III)-chelating agent-conjugated P22 viral capsids (outer diameter: 64 nm) are dramatically increased as compared to both free Gd(III)-chelating agents and Gd(III)-chelating agent-conjugated ferritins (outer diameter: 12 nm), suggesting that the large sized P22 viral capsids exhibit a much slower tumbling rate, which results in a faster T1 relaxation rate. Gd(III)-chelating agents are attached to either the interior or exterior surface of P22 viral capsids and the conjugation positions of Gd(III)-chelating agents, however, do not have a significant effect on the relaxivity values of the macromolecular conjugates. The contrast enhancement of Gd(III)-chelating agent-conjugated P22 viral capsids is confirmed by in vitro phantom imaging at a short repetition times (TR) and the potential usage of Gd(III)-chelating agent-conjugated P22 viral capsids for in vivo MR imaging is validated by visualizing a mouse's intravascular system, including the carotid, mammary arteries, the jugular vein, and the superficial vessels of the head at an isotropic resolution of 250 μm. | - |
dc.identifier.bibliographicCitation | BIOMACROMOLECULES, v.14, no.7, pp.2332 - 2339 | - |
dc.identifier.doi | 10.1021/bm400461j | - |
dc.identifier.issn | 1525-7797 | - |
dc.identifier.scopusid | 2-s2.0-84880071463 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/4253 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84880071463 | - |
dc.identifier.wosid | 000321793700023 | - |
dc.language | 영어 | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Implementation of P22 Viral Capsids As Intravascular Magnetic Resonance T-1 Contrast Conjugates via Site-Selective Attachment of Gd(III)-Chelating Agents | - |
dc.type | Article | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Chemistry, Organic; Polymer Science | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Chemistry; Polymer Science | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | SUPERPARAMAGNETIC IRON-OXIDE | - |
dc.subject.keywordPlus | HIGH-RELAXIVITY | - |
dc.subject.keywordPlus | ATHEROSCLEROTIC PLAQUE | - |
dc.subject.keywordPlus | HYPERLIPIDEMIC RABBITS | - |
dc.subject.keywordPlus | NANOPARTICLE PROBES | - |
dc.subject.keywordPlus | FIELD STRENGTH | - |
dc.subject.keywordPlus | MRI | - |
dc.subject.keywordPlus | GADOLINIUM | - |
dc.subject.keywordPlus | MATURATION | - |
dc.subject.keywordPlus | DESIGN | - |
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