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- Hong, Sung You
- Synthetic Organic Chemistry Lab.
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Polyvalent display of monosaccharides on ferritin protein cage nanoparticles for the recognition and binding of cell-surface lectins
- Author(s)
- Kang, Young Ji, Yang, Hyun Ji, Jeon, Sangbin, Kang, Young-Sun, Do, Yoonkyung, Hong, Sung You, Kang, Sebyung
- Issued Date
- 2014-05
- Citation
- MACROMOLECULAR BIOSCIENCE, v.14, no.5, pp.619 - 625
- Abstract
- Carbohydrate-lectin interactions are important in many biological events. Endogenous cell-surface lectins are attractive markers for the recognition and targeting. Human ferritin protein cage nanoparticles (HFPCNs) are prepared as delivery nanoplatforms and two different types of monosaccharide derivatives; maleimido group terminated-mannopyranoside and galactopyranoside. Uniform and polyvalent displays of mannoses or galactoses on the surface of HFPCNs are achieved by using site-specific thiol-maleimide Michael-type addition. Mannose- or galactose-displaying HFPCNs recognize and tightly bind to DC-SIGN or ASGP-R lectins on the surface of the mammalian cells, DCEK or HepG2 cells.
- Publisher
- WILEY-V C H VERLAG GMBH
- ISSN
- 1616-5187
- Keyword (Author)
- cell-surface lectins, delivery nanoplatforms, glycoconjugates, polyvalent display, protein cages
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