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DC Field | Value | Language |
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dc.citation.endPage | 2178 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 2171 | - |
dc.citation.title | BIOMACROMOLECULES | - |
dc.citation.volume | 14 | - |
dc.contributor.author | Oikawa, Yurie | - |
dc.contributor.author | Lee, Sueun | - |
dc.contributor.author | Kim, Do Hyung | - |
dc.contributor.author | Kang, Dae Hwan | - |
dc.contributor.author | Kim, Byeong-Su | - |
dc.contributor.author | Saito, Kyohei | - |
dc.contributor.author | Sasaki, Shigeko | - |
dc.contributor.author | Oishi, Yoshiyuki | - |
dc.contributor.author | Shibasaki, Yuji | - |
dc.date.accessioned | 2023-12-22T03:43:03Z | - |
dc.date.available | 2023-12-22T03:43:03Z | - |
dc.date.created | 2013-08-28 | - |
dc.date.issued | 2013-07 | - |
dc.description.abstract | This paper describes the one-pot synthesis of a polyglycidol (PG)-based polymer, poly(ethoxyethyl glycidyl ether) (PEEGE)-b-[hyperbranched polyglycerol (hbPG)-co-PEEGE]x/y, its micelle formulation, and the ability to encapsulate a model therapeutic molecule. Amphiphilic block copolymers were prepared by the sequential addition of ethoxyethyl glycidyl ether (EEGE) to glycidol. The composition of the block copolymers varied from 62:38 to 92:8. Block copolymers with composition x:y ≥ 66:34 were soluble only in organic solvents. Micelles were formulated by injection of deionized water into a tetrahydrofuran block copolymer solution with or without pyrene as a model hydrophobic molecule. The critical micelle concentration was 18.2-30.9 mg/L, and the micelle size was 100-250 nm. The pyrene-containing micelle rapidly collapsed on acidic exposure, allowing conversion of hydrophobic PEEGE to hydrophilic PG, thus, facilitating the release of the encapsulated pyrene. Cytotoxicity data showed high biocompatibility of PG-based block copolymers, suggesting their potential as a drug delivery carrier. | - |
dc.identifier.bibliographicCitation | BIOMACROMOLECULES, v.14, no.7, pp.2171 - 2178 | - |
dc.identifier.doi | 10.1021/bm400275w | - |
dc.identifier.issn | 1525-7797 | - |
dc.identifier.scopusid | 2-s2.0-84880051409 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/4032 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84880051409 | - |
dc.identifier.wosid | 000321793700006 | - |
dc.language | 영어 | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | One-Pot Synthesis of Linear-Hyperbranched Amphiphilic Block Copolymers Based on Polyglycerol Derivatives and Their Micelles | - |
dc.type | Article | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Chemistry, Organic; Polymer Science | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Chemistry; Polymer Science | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | SELF-ASSEMBLED MONOLAYERS | - |
dc.subject.keywordPlus | POLY(ETHYLENE OXIDE) | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | POLYMERIZATION | - |
dc.subject.keywordPlus | POLYMERS | - |
dc.subject.keywordPlus | GLYCIDOL | - |
dc.subject.keywordPlus | FLUORESCENCE | - |
dc.subject.keywordPlus | POLYSTYRENE | - |
dc.subject.keywordPlus | ADSORPTION | - |
dc.subject.keywordPlus | GOLD | - |
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