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Author

Kim, Byeong-Su
Soft and Hybrid Nanomaterials Lab
Research Interests
  • Carbon materials, polymer, Layer-by-Layer (LbL) assembly, hyperbranched polymer, polyglycerol (PG), bio-applications

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One-Pot Synthesis of Linear-Hyperbranched Amphiphilic Block Copolymers Based on Polyglycerol Derivatives and Their Micelles

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Title
One-Pot Synthesis of Linear-Hyperbranched Amphiphilic Block Copolymers Based on Polyglycerol Derivatives and Their Micelles
Author
Oikawa, YurieLee, SueunKim, Do HyungKang, Dae HwanKim, Byeong-SuSaito, KyoheiSasaki, ShigekoOishi, YoshiyukiShibasaki, Yuji
Keywords
Amphiphilic block copolymers; Copolymer solution; Drug delivery carrier; Hydrophobic molecules; Hyperbranched polyglycerol; Poly(ethoxyethyl glycidyl ether); Sequential addition; Therapeutic molecules
Issue Date
201307
Publisher
AMER CHEMICAL SOC
Citation
BIOMACROMOLECULES, v.14, no.7, pp.2171 - 2178
Abstract
This paper describes the one-pot synthesis of a polyglycidol (PG)-based polymer, poly(ethoxyethyl glycidyl ether) (PEEGE)-b-[hyperbranched polyglycerol (hbPG)-co-PEEGE]x/y, its micelle formulation, and the ability to encapsulate a model therapeutic molecule. Amphiphilic block copolymers were prepared by the sequential addition of ethoxyethyl glycidyl ether (EEGE) to glycidol. The composition of the block copolymers varied from 62:38 to 92:8. Block copolymers with composition x:y ≥ 66:34 were soluble only in organic solvents. Micelles were formulated by injection of deionized water into a tetrahydrofuran block copolymer solution with or without pyrene as a model hydrophobic molecule. The critical micelle concentration was 18.2-30.9 mg/L, and the micelle size was 100-250 nm. The pyrene-containing micelle rapidly collapsed on acidic exposure, allowing conversion of hydrophobic PEEGE to hydrophilic PG, thus, facilitating the release of the encapsulated pyrene. Cytotoxicity data showed high biocompatibility of PG-based block copolymers, suggesting their potential as a drug delivery carrier.
URI
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DOI
http://dx.doi.org/10.1021/bm400275w
ISSN
1525-7797
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