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dc.citation.endPage 1550 -
dc.citation.number 11 -
dc.citation.startPage 1544 -
dc.citation.title NATURE NEUROSCIENCE -
dc.citation.volume 16 -
dc.contributor.author Lim, Chunghun -
dc.contributor.author Allada, Ravi -
dc.date.accessioned 2023-12-22T03:15:06Z -
dc.date.available 2023-12-22T03:15:06Z -
dc.date.created 2013-11-05 -
dc.date.issued 2013-11 -
dc.description.abstract Circadian clocks temporally organize behavior and physiology across the 24-h day. Great progress has been made in understanding the molecular basis of timekeeping, with a focus on transcriptional feedback networks that are post-translationally modulated. Yet emerging evidence indicates an important role for post-transcriptional regulation, from splicing, polyadenylation and mRNA stability to translation and non-coding functions exemplified by microRNAs. This level of regulation affects virtually all aspects of circadian systems, from the core timing mechanism and input pathways that synchronize clocks to the environment and output pathways that control overt rhythmicity. We hypothesize that post-transcriptional control confers on circadian clocks enhanced robustness as well as the ability to adapt to different environments. As much of what is known derives from nonneural cells or tissues, future work will be required to investigate the role of post-transcriptional regulation in neural clocks. -
dc.identifier.bibliographicCitation NATURE NEUROSCIENCE, v.16, no.11, pp.1544 - 1550 -
dc.identifier.doi 10.1038/nn.3543 -
dc.identifier.issn 1097-6256 -
dc.identifier.scopusid 2-s2.0-84886813829 -
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/4002 -
dc.identifier.url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84886813829 -
dc.identifier.wosid 000326205700010 -
dc.language 영어 -
dc.publisher NATURE PUBLISHING GROUP -
dc.title Emerging roles for post-transcriptional regulation in circadian clocks -
dc.type Article -
dc.description.isOpenAccess FALSE -
dc.relation.journalWebOfScienceCategory Neurosciences -
dc.relation.journalResearchArea Neurosciences & Neurology -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -

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