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Lim, Chunghun
Neurogenetics & Ribonomics Laboratory (The Lim Lab)
Research Interests
  • Post-transcriptional Gene Expression, Neurodegeneration, Behavioral Genetics

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Emerging roles for post-transcriptional regulation in circadian clocks

Cited 5 times inthomson ciCited 4 times inthomson ci
Title
Emerging roles for post-transcriptional regulation in circadian clocks
Author
Lim, ChunghunAllada, Ravi
Keywords
TRANSLATIONAL PROFILING APPROACH; NONOPTIMAL CODON USAGE; CNS CELL-TYPES; MESSENGER-RNA; GENE-EXPRESSION; HNRNP-Q; DROSOPHILA CLOCK; DEPENDENT TRANSLATION; PROTEIN EXPRESSION; PHOSPHOLIPASE-C
Issue Date
201311
Publisher
NATURE PUBLISHING GROUP
Citation
NATURE NEUROSCIENCE, v.16, no.11, pp.1544 - 1550
Abstract
Circadian clocks temporally organize behavior and physiology across the 24-h day. Great progress has been made in understanding the molecular basis of timekeeping, with a focus on transcriptional feedback networks that are post-translationally modulated. Yet emerging evidence indicates an important role for post-transcriptional regulation, from splicing, polyadenylation and mRNA stability to translation and non-coding functions exemplified by microRNAs. This level of regulation affects virtually all aspects of circadian systems, from the core timing mechanism and input pathways that synchronize clocks to the environment and output pathways that control overt rhythmicity. We hypothesize that post-transcriptional control confers on circadian clocks enhanced robustness as well as the ability to adapt to different environments. As much of what is known derives from nonneural cells or tissues, future work will be required to investigate the role of post-transcriptional regulation in neural clocks.
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DOI
http://dx.doi.org/10.1038/nn.3543
ISSN
1097-6256
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