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Author

Hong, Sung You
Synthetic Organic Chemistry Laboratory
Research Interests
  • Synthetic organic chemistry, transition metals, oxidation state

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Development of P22 Viral Capsid Nanocomposites as Anti-Cancer Drug, Bortezomib (BTZ), Delivery Nanoplatforms

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Title
Development of P22 Viral Capsid Nanocomposites as Anti-Cancer Drug, Bortezomib (BTZ), Delivery Nanoplatforms
Author
Min, JunseonMoon, HyojinYang, Hyun JiShin, Hyun-HeeHong, Sung YouKang, Sebyung
Keywords
BTZ; Catechol ligands; Drug delivery; Hepatocellular carcinoma cells; Viral capsids
Issue Date
201404
Publisher
WILEY-V C H VERLAG GMBH
Citation
MACROMOLECULAR BIOSCIENCE, v.14, no.4, pp.557 - 564
Abstract
Genetic and chemical engineering approaches are used to employ P22 viral capsids as nanoplatforms for developing an efficient delivery vehicle. Catechol ligands are chemically attached to the interior surface of P22 viral capsid for subsequent encapsulation of an anticancer drug, bortezomib (BTZ), through boronic acid-diol complexation. For targeted delivery, hepatocellular carcinoma (HCC)-targeting peptide (SP94, SFSIIHTPILPL) is synthesized and chemically conjugated to the exterior surface of the P22 viral capsid nanocomposites. Effective targeted delivery of synthesized P22 viral capsid nanocomposites is demonstrated by fluorescent cell imaging and the efficacy of delivered P22 viral capsid nanocomposites is evaluated using a cell viability assay.
URI
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DOI
http://dx.doi.org/10.1002/mabi.201300401
ISSN
1616-5187
Appears in Collections:
SLS_Journal Papers
ECHE_Journal Papers

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