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Author

Seo, Jeong Kon
UNIST Central Research Facilities (UCRF)
Research Interests
  • Discovery of novel bioactive peptides

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Oxidized low-density lipoprotein-induced foam cell formation is mediated by formyl peptide receptor 2

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Title
Oxidized low-density lipoprotein-induced foam cell formation is mediated by formyl peptide receptor 2
Author
Lee, Ha YoungOh, EunseoKim, Sang DooSeo, Jeong KonBae, Yoe-Sik
Keywords
Atherosclerosis; Foam cell; Formyl peptide receptor 2; Oxidized LDL
Issue Date
201401
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Citation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.443, no.3, pp.1003 - 1007
Abstract
The increased level of LDL and its modification into oxLDL has been regarded as an important risk factor for the development of cardiovascular diseases such as atherosclerosis. Although some scavenger receptors including CD36 and RAGE have been considered as target receptors for oxLDL, involvement of other receptors should be investigated for oxLDL-induced pathological responses. In this study, we found that oxLDL-induced foam cell formation was inhibited by formyl peptide receptor 2 (FPR2) antagonist WRW4. oxLDL also stimulated calcium signaling and chemotactic migration in FPR2-expressing RBL-2H3 cells but not in vector-expressing RBL-2H3 cells. Moreover, oxLDL stimulated TNF-α production, which was also almost completely inhibited by FPR2 antagonist. Our findings therefore suggest that oxLDL stimulates macrophages, resulting in chemotactic migration, TNF-α production, and foam cell formation via FPR2 signaling, and thus likely contributes to atherogenesis.
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DOI
http://dx.doi.org/10.1016/j.bbrc.2013.12.082
ISSN
0006-291X
Appears in Collections:
UCRF_Journal Papers

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